GRADIENT HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ASSAY OF THE RADIOSENSITIZERS ETANIDAZOLE (SR-2508) AND PIMONIDAZOLE (RO-03-8799) IN BIOLOGICAL-MATERIALS

被引：9

作者：

WARD, R ^{[1
]}

WORKMAN, P ^{[1
]}

机构：

[1] MRC,CLIN ONCOL & RADIOTHERAPEUT UNIT,HILLS RD,CAMBRIDGE CB2 2QH,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1987年 / 420卷 / 01期

关键词：

D O I：

10.1016/0378-4347(87)80178-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

引用

页码：223 / 227

页数：5

共 9 条

[1] PARTITION-COEFFICIENT AS A GUIDE TO THE DEVELOPMENT OF RADIOSENSITIZERS WHICH ARE LESS TOXIC THAN MISONIDAZOLE
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WORKMAN, P
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[2] INITIAL REPORT OF THE PHASE-I TRIAL OF THE HYPOXIC CELL RADIOSENSITIZER SR-2508
COLEMAN, CN
URTASUN, RC
WASSERMAN, TH
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HIRST, VK
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (09): : 1749 - 1753
[3] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF THE NEW HYPOXIC CELL RADIOSENSITIZER, RO 03-8799, IN BIOLOGICAL SAMPLES
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LEE, A
GROVES, JK
[J]. JOURNAL OF CHROMATOGRAPHY, 1983, 273 (02): : 327 - 333
[4] MINCHINTON AI, 1986, THESIS U LONDON LOND
[5] A PHASE-I STUDY OF THE COMBINED HYPOXIC CELL RADIOSENSITIZERS, RO 03-8799 AND SR 2508 - A PRELIMINARY-REPORT OF SINGLE-DOSE TOXICITY, PHARMACOKINETICS AND TUMOR CONCENTRATIONS
NEWMAN, HFV
BLEEHEN, NM
WORKMAN, P
[J]. BRITISH JOURNAL OF RADIOLOGY, 1986, 59 (700) : 423 - 425
[6] A PHASE-I STUDY OF THE COMBINATION OF 2 HYPOXIC CELL RADIOSENSITIZERS, RO-03-8799 AND SR-2508 - TOXICITY AND PHARMACOKINETICS
NEWMAN, HFV
BLEEHEN, NM
WORKMAN, P
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1986, 12 (07): : 1113 - 1116
[7] A CLINICAL PHASE-1 TOXICITY STUDY OF RO-03-8799 - PLASMA, URINE, TUMOR AND NORMAL BRAIN PHARMACOKINETICS
ROBERTS, JT
BLEEHEN, NM
WALTON, MI
WORKMAN, P
[J]. BRITISH JOURNAL OF RADIOLOGY, 1986, 59 (698) : 107 - 116
[8] THE CLINICAL-TESTING OF RO 03-8799 PHARMACOKINETICS, TOXICOLOGY, TISSUE AND TUMOR CONCENTRATIONS
SAUNDERS, MI
ANDERSON, PJ
BENNETT, MH
DISCHE, S
MINCHINTON, A
STRATFORD, MRL
TOTHILL, M
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (09): : 1759 - 1763
[9] ESTIMATION OF HYPOXIC CELL-SENSITIZER MISONIDAZOLE AND ITS O-DEMETHYLATED METABOLITE IN BIOLOGICAL-MATERIALS BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
WORKMAN, P
LITTLE, CJ
MARTEN, TR
DALE, AD
RUANE, RJ
FLOCKHART, IR
BLEEHEN, NM
[J]. JOURNAL OF CHROMATOGRAPHY, 1978, 145 (03): : 507 - 512

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