ENANTIOSELECTIVE SYNTHESIS OF BETA,BETA-DIFLUOROMALIC ACID VIA ENZYMATIC RESOLUTION OF FURYL SUBSTITUTED DERIVATIVE

被引：13

作者：

TSUKAMOTO, T ^{[1
]}

YOSHIYAMA, T ^{[1
]}

KITAZUME, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL,DEPT BIOENGN,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1991年 / 2卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(00)80453-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(R)-and (S)-N,N-Diethyl 2,2-difluoro-3-(2-furyl)-3-hydroxypropionamide 7 have been obtained via enzymic resolution of the racemic acetate using lipase MY from Candida cylindracea. Ozonolysis of the (S)-7 followed by hydrolysis afforded the (S)-beta,beta-difluoromalic acid 1.

引用

页码：759 / 762

页数：4

共 23 条

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