PYRIPYROPENES, NOVEL ACAT INHIBITORS PRODUCED BY ASPERGILLUS-FUMIGATUS .3. STRUCTURE ELUCIDATION OF PYRIPYROPENES E TO L

被引：58

作者：

TOMODA, H ^{[1
]}

TABATA, N ^{[1
]}

YANG, DJ ^{[1
]}

TAKAYANAGI, H ^{[1
]}

NISHIDA, H ^{[1
]}

OMURA, S ^{[1
]}

KANEKO, T ^{[1
]}

机构：

[1] PFIZER INC,DIV CENT RES,GROTON,CT 06340

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 06期

关键词：

D O I：

10.7164/antibiotics.48.495

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Eight new pyripyropenes, E to L, were isolated from the culture broth of Aspergillus fumigatus FO-1289-2501 selected as a higher producer by NTG mutation. Structural elucidation indicated that all the pyripyropenes have the same pyridino-alpha-pyrone sesquiterpene core as pyripyropenes A to D. Among them, pyripyropene L showed the most potent inhibition against acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 value of 0.27 mu M in rat liver microsomes.

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页码：495 / 503

页数：9

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