INFECTION WITH ADENOASSOCIATED VIRUS TYPE-5 INHIBITS MUTAGENICITY OF HERPES-SIMPLEX VIRUS TYPE-1 OR 4-NITROQUINOLINE-1-OXIDE

被引:12
作者
SCHLEHOFER, JR
HEILBRONN, R
机构
[1] Deutsches Krebsforschungszentrum
来源
MUTATION RESEARCH | 1990年 / 244卷 / 04期
关键词
Adeno-associated virus; Herpes simplex virus; HPRT; Human rhabdomyosarcoma cells; Inhibition of mutagenicity;
D O I
10.1016/0165-7992(90)90079-Y
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Infection with adeno-associated virus type (AAV-5) reduced the number of mutants arising in the hypoxanthine phosphoribosyltransferase locus of human RD 176 cells after infection with herpes simplex virus type 1 (HSV-1; partially inactivated) or 4-nitroquinoline-1-oxide (4-NQO). The mutation frequency was reduced by AAV-5 infection from 11.4 to 1.8 after mutation with HSV-1 and from 3.2 to 2.5 when mutation was induced by 4-NQO. This was analyzed by determination of the number of cells resistant to 8-azaguanine when infected with AAV-5 prior to induction of mutations with HSV-1 or 4-NQO. © 1990.
引用
收藏
页码:317 / 320
页数:4
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