INFECTION WITH ADENOASSOCIATED VIRUS TYPE-5 INHIBITS MUTAGENICITY OF HERPES-SIMPLEX VIRUS TYPE-1 OR 4-NITROQUINOLINE-1-OXIDE

被引：12

作者：

SCHLEHOFER, JR

HEILBRONN, R

机构：

[1] Deutsches Krebsforschungszentrum

来源：

MUTATION RESEARCH | 1990年 / 244卷 / 04期

关键词：

Adeno-associated virus; Herpes simplex virus; HPRT; Human rhabdomyosarcoma cells; Inhibition of mutagenicity;

D O I：

10.1016/0165-7992(90)90079-Y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Infection with adeno-associated virus type (AAV-5) reduced the number of mutants arising in the hypoxanthine phosphoribosyltransferase locus of human RD 176 cells after infection with herpes simplex virus type 1 (HSV-1; partially inactivated) or 4-nitroquinoline-1-oxide (4-NQO). The mutation frequency was reduced by AAV-5 infection from 11.4 to 1.8 after mutation with HSV-1 and from 3.2 to 2.5 when mutation was induced by 4-NQO. This was analyzed by determination of the number of cells resistant to 8-azaguanine when infected with AAV-5 prior to induction of mutations with HSV-1 or 4-NQO. © 1990.

引用

收藏

页码：317 / 320

页数：4

相关论文

共 31 条

[21] INHIBITION OF ADENOVIRUS-TRANSFORMED CELL ONCOGENICITY BY ADENO-ASSOCIATED VIRUS [J].

OSTROVE, JM ;

DUCKWORTH, DH ;

BERNS, KI .

VIROLOGY, 1981, 113 (02) :521-533

[22] INCREASED MUTATION FREQUENCY AFTER HERPES-SIMPLEX VIRUS TYPE-2 INFECTION IN NON-PERMISSIVE XC CELLS [J].

PILON, L ;

ROYAL, A ;

LANGELIER, Y .

JOURNAL OF GENERAL VIROLOGY, 1985, 66 (FEB) :259-265

[23] STABLE INTEGRATION OF ADENOVIRUS DNA IS NOT REQUIRED FOR THE INDUCTION OF MUTATIONS IN THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE GENE IN CHINESE-HAMSTER CELLS [J].

RAPTIS, L ;

DESOUZA, AC ;

MBIKAY, M ;

THIRION, JP ;

WEBER, J .

MUTATION RESEARCH, 1982, 105 (05) :371-375

[24] INHIBITION OF INITIATOR-INDUCED SV40 GENE AMPLIFICATION IN SV40-TRANSFORMED CHINESE-HAMSTER CELLS BY INFECTION WITH A DEFECTIVE PARVOVIRUS [J].

SCHLEHOFER, JR ;

HEILBRONN, R ;

GEORGFRIES, B ;

HAUSEN, HZ .

INTERNATIONAL JOURNAL OF CANCER, 1983, 32 (05) :591-595

[25] VACCINIA VIRUS, HERPES-SIMPLEX VIRUS, AND CARCINOGENS INDUCE DNA AMPLIFICATION IN A HUMAN CELL-LINE AND SUPPORT REPLICATION OF A HELPERVIRUS DEPENDENT PARVOVIRUS [J].

SCHLEHOFER, JR ;

EHRBAR, M ;

HAUSEN, HZ .

VIROLOGY, 1986, 152 (01) :110-117

[26] INDUCTION OF MUTATIONS WITHIN THE HOST-CELL GENOME BY PARTIALLY INACTIVATED HERPES-SIMPLEX VIRUS TYPE-1 [J].

SCHLEHOFER, JR ;

HAUSEN, HZ .

VIROLOGY, 1982, 122 (02) :471-475

[27] HERPES-SIMPLEX VIRUS-INDUCED AMPLIFICATION OF SV40 SEQUENCES IN TRANSFORMED CHINESE-HAMSTER EMBRYO CELLS [J].

SCHLEHOFER, JR ;

GISSMANN, L ;

MATZ, B ;

ZURHAUSEN, H .

INTERNATIONAL JOURNAL OF CANCER, 1983, 32 (01) :99-103

[28]

SCHLEHOFER JR, 1990, UNPUB ADENOVIRUS INF

[29]

SCHLEHOFER JR, 1990, UNPUB DOWN REGULATIO

[30] AMPLIFICATION OF BOVINE PAPILLOMAVIRUS DNA BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, ULTRAVIOLET-IRRADIATION, OR INFECTION WITH HERPES-SIMPLEX VIRUS [J].

SCHMITT, J ;

SCHLEHOFER, JR ;

MERGENER, K ;

GISSMANN, L ;

ZURHAUSEN, H .

VIROLOGY, 1989, 172 (01) :73-81

← 1 2 3 4 →