INFECTION WITH ADENOASSOCIATED VIRUS TYPE-5 INHIBITS MUTAGENICITY OF HERPES-SIMPLEX VIRUS TYPE-1 OR 4-NITROQUINOLINE-1-OXIDE

被引：12

作者：

SCHLEHOFER, JR

HEILBRONN, R

机构：

[1] Deutsches Krebsforschungszentrum

来源：

MUTATION RESEARCH | 1990年 / 244卷 / 04期

关键词：

Adeno-associated virus; Herpes simplex virus; HPRT; Human rhabdomyosarcoma cells; Inhibition of mutagenicity;

D O I：

10.1016/0165-7992(90)90079-Y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Infection with adeno-associated virus type (AAV-5) reduced the number of mutants arising in the hypoxanthine phosphoribosyltransferase locus of human RD 176 cells after infection with herpes simplex virus type 1 (HSV-1; partially inactivated) or 4-nitroquinoline-1-oxide (4-NQO). The mutation frequency was reduced by AAV-5 infection from 11.4 to 1.8 after mutation with HSV-1 and from 3.2 to 2.5 when mutation was induced by 4-NQO. This was analyzed by determination of the number of cells resistant to 8-azaguanine when infected with AAV-5 prior to induction of mutations with HSV-1 or 4-NQO. © 1990.

引用

页码：317 / 320

页数：4