PRACTICAL, STEREOCONTROLLED SYNTHESIS OF 2-FUNCTIONALIZED-METHYL-1 BETA-METHYLCARBAPENEMS

被引：13

作者：

UYEO, S

ITANI, H

机构：

[1] Shionogi Research Laboratories Shionogi, Co., Ltd., Fukushima-ku, Osaka

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 25期

关键词：

D O I：

10.1016/S0040-4039(00)73360-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of acetoxy-azetidinone 4, (Z)-crotylbromide 5 and Zn selectively gave 6, which was convened to 1 beta-methyl-2-(hydroxymethyl)carbapenem 11, a key intermediate in synthesis of antibiotic 2, in high overall yield.

引用

页码：4377 / 4378

页数：2

共 9 条

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[9] A SIMPLE AND STEREOCONTROLLED SYNTHESIS OF A 1-BETA-METHYLCARBAPENEM KEY INTERMEDIATE BY MEANS OF ORGANOSILICON CHEMISTRY
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ITANI, H
[J]. TETRAHEDRON LETTERS, 1991, 32 (19) : 2143 - 2144

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