ANHYDRORETINOL - A NATURALLY-OCCURRING INHIBITOR OF LYMPHOCYTE PHYSIOLOGY

被引:90
作者
BUCK, J
GRUN, F
DERGUINI, F
CHEN, Y
KIMURA, S
NOY, N
HAMMERLING, U
机构
[1] MEM SLOAN KETTERING CANC CTR,IMMUNOL PROGRAM,1275 YORK AVE,NEW YORK,NY 10021
[2] CORNELL UNIV,MED CTR,COLL MED,DEPT MED,NEW YORK,NY 10021
[3] CORNELL UNIV,MED CTR,COLL MED,DEPT PHARMACOL,NEW YORK,NY 10021
[4] COLUMBIA UNIV,DEPT MED,NEW YORK,NY 10027
关键词
D O I
10.1084/jem.178.2.675
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Vitamin A (retinol) is an essential cofactor for growth of B lymphocytes in culture and for activation of T lymphocytes by antigen receptor-mediated signals. 14-hydroxy-4,14-retro-retinol (14-HRR) a metabolite of retinol, has been implicated as the intracellular mediator of this effect. Anhydroretinol (AR) is a retinol derivative with retro structure produced in activated human B lymphocytes and the insect cell lines SF 21 and Schneider S2. AR reversibly inhibits retinol- and 14-HRR-dependent effects and blocks B lymphocyte proliferation as well as activation of resting T lymphocytes. The intracellular signaling pathway blocked by AR in T cell activation is distinct from the calcineurin/interleukin 2 pathway inhibitable by cyclosporine A or FK-506.
引用
收藏
页码:675 / 680
页数:6
相关论文
共 28 条
  • [11] PURIFICATION OF PREALBUMIN FROM HUMAN AND CANINE SERUM USING A 2-STEP AFFINITY CHROMATOGRAPHIC PROCEDURE
    FEX, G
    LAURELL, CB
    THULIN, E
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 75 (01): : 181 - 186
  • [12] RETINOIDS ARE IMPORTANT COFACTORS IN T-CELL ACTIVATION
    GARBE, A
    BUCK, J
    HAMMERLING, U
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (01) : 109 - 117
  • [13] IDENTIFICATION OF A RECEPTOR FOR THE MORPHOGEN RETINOIC ACID
    GIGUERE, V
    ONG, ES
    SEGUI, P
    EVANS, RM
    [J]. NATURE, 1987, 330 (6149) : 624 - 629
  • [14] LONG-TERM CULTURE OF TUMOR-SPECIFIC CYTOTOXIC T-CELLS
    GILLIS, S
    SMITH, KA
    [J]. NATURE, 1977, 268 (5616) : 154 - 156
  • [15] CYCLOPHILIN - A SPECIFIC CYTOSOLIC BINDING-PROTEIN FOR CYCLOSPORIN-A
    HANDSCHUMACHER, RE
    HARDING, MW
    RICE, J
    DRUGGE, RJ
    [J]. SCIENCE, 1984, 226 (4674) : 544 - 547
  • [16] HOWELL JMG, 1963, J REPROD FERTIL, V5, P159, DOI 10.1530/jrf.0.0050159
  • [17] IDENTIFICATION OF A MONOCLONAL-ANTIBODY SPECIFIC FOR A MURINE T3 POLYPEPTIDE
    LEO, O
    FOO, M
    SACHS, DH
    SAMELSON, LE
    BLUESTONE, JA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) : 1374 - 1378
  • [18] NUCLEAR RECEPTOR THAT IDENTIFIES A NOVEL RETINOIC ACID RESPONSE PATHWAY
    MANGELSDORF, DJ
    ONG, ES
    DYCK, JA
    EVANS, RM
    [J]. NATURE, 1990, 345 (6272) : 224 - 229
  • [19] MCCLEAN SW, 1982, CLIN CHEM, V28, P693
  • [20] Ong D, 1980, Methods Enzymol, V67, P288