NEUROMEDIATOR ANALOGS - SYNTHESIS OF CIS (2R,3S) AND TRANS (2S,3S)-2,3-PIPERIDINE DICARBOXYLIC-ACIDS FROM (2S)-2-PHENYLGLYCINOL

被引:23
作者
AGAMI, C [1 ]
KADOURIPUCHOT, C [1 ]
LEGUEN, V [1 ]
VAISSERMANN, J [1 ]
机构
[1] UNIV PARIS 06,CNRS,CHIM MET TRANSIT LAB,F-75005 PARIS,FRANCE
关键词
D O I
10.1016/0040-4039(95)00088-T
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The cis and trans isomers of 2,3-piperidine dicarboxylic acids were obtained in enantiopure forms from the same chiral inductor: 2-phenylglycinol. This synthesis was mainly based on a delta-lactam formation via Stille's aza-annulation/hydrogenation procedure which includes here an asymmetric induction.
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页码:1657 / 1660
页数:4
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