PROTECTION OF GOATS AGAINST PESTE DES PETITS RUMINANTS WITH RECOMBINANT CAPRIPOXVIRUSES EXPRESSING THE FUSION AND HEMAGGLUTININ PROTEIN GENES OF RINDERPEST VIRUS

被引：48

作者：

ROMERO, CH ^{[1
]}

BARRETT, T ^{[1
]}

KITCHING, RP ^{[1
]}

BOSTOCK, C ^{[1
]}

BLACK, DN ^{[1
]}

机构：

[1] BBSRC,INST ANIM HLTH,PIRBRIGHT LAB,WOKING GU24 0NF,SURREY,ENGLAND

来源：

VACCINE | 1995年 / 13卷 / 01期

基金：

英国惠康基金;

关键词：

PESTE DES PETITS RUMINANTS; RECOMBINANT VACCINE; F AND H GENES;

D O I：

10.1016/0264-410X(95)80008-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Goats were protected against a lethal challenge of peste des petits ruminants (PPR) virus following vaccination with a recombinant capripoxvirus containing either the fusion (F) gene of rinderpest virus or the haemagglutinin (H) gene of rinderpest virus. The H gene recombinant produced high titres of neutralizing antibody to rinderpest virus in the vaccinated goats, whereas the F gene recombinant failed to stimulate detectable levels of neutralizing antibody. A similar response to the two recombinant vaccines has previously been reported for cattle. Neither recombinant produced detectable levels of specific antibodies to PPR virus.

引用

页码：36 / 40

页数：5

共 12 条

[1]

Diallo A, 1989, Rev Elev Med Vet Pays Trop, V42, P311

[2] THE NUCLEOTIDE-SEQUENCE AROUND THE CAPRIPOXVIRUS THYMIDINE KINASE GENE REVEALS A GENE SHARED SPECIFICALLY WITH LEPORIPOXVIRUS [J].

GERSHON, PD ;

BLACK, DN .

JOURNAL OF GENERAL VIROLOGY, 1989, 70 :525-533

[3] PROTECTION OF GOATS AGAINST PESTE DES PETITS RUMINANTS WITH A VACCINIA VIRUS DOUBLE RECOMBINANT EXPRESSING THE F-GENE AND H-GENE OF RINDERPEST VIRUS [J].

JONES, L ;

GIAVEDONI, L ;

SALIKI, JT ;

BROWN, C ;

MEBUS, C ;

YILMA, T .

VACCINE, 1993, 11 (09) :961-964

[4]

Kitching R P, 1986, Rev Sci Tech, V5, P503, DOI 10.20506/rst.5.2.241

[5] A SINGLE VACCINE FOR THE CONTROL OF CAPRIPOX INFECTION IN SHEEP AND GOATS [J].

KITCHING, RP ;

HAMMOND, JM ;

TAYLOR, WP .

RESEARCH IN VETERINARY SCIENCE, 1987, 42 (01) :53-60

[6] THE USE OF THERMOSTABLE VERO CELL-ADAPTED RINDERPEST VACCINE AS A HETEROLOGOUS VACCINE AGAINST PESTE-DES-PETITS RUMINANTS [J].

MARINER, JC ;

HOUSE, JA ;

MEBUS, CA ;

VANDENENDE, MC .

RESEARCH IN VETERINARY SCIENCE, 1993, 54 (02) :212-216

[7] RECOMBINANT CAPRIPOXVIRUS EXPRESSING THE HEMAGGLUTININ PROTEIN GENE OF RINDERPEST VIRUS - PROTECTION OF CATTLE AGAINST RINDERPEST AND LUMPY SKIN-DISEASE VIRUSES [J].

ROMERO, CH ;

BARRETT, T ;

CHAMBERLAIN, RW ;

KITCHING, RP ;

FLEMING, M ;

BLACK, DN .

VIROLOGY, 1994, 204 (01) :425-429

[8] SINGLE CAPRIPOXVIRUS RECOMBINANT VACCINE FOR THE PROTECTION OF CATTLE AGAINST RINDERPEST AND LUMPY SKIN-DISEASE [J].

ROMERO, CH ;

BARRETT, T ;

EVANS, SA ;

KITCHING, RP ;

GERSHON, PD ;

BOSTOCK, C ;

BLACK, DN .

VACCINE, 1993, 11 (07) :737-742

[9] PROTECTION OF GOATS AGAINST PESTE-DES-PETITS-RUMINANTS WITH ATTENUATED RINDERPEST VIRUS [J].

TAYLOR, WP .

RESEARCH IN VETERINARY SCIENCE, 1979, 27 (03) :321-324

[10] HUMAN HLA CLASS I-RESTRICTED AND HLA CLASS II-RESTRICTED CLONED CYTOTOXIC T-LYMPHOCYTES IDENTIFY A CLUSTER OF EPITOPES ON THE MEASLES-VIRUS FUSION PROTEIN [J].

VANBINNENDIJK, RS ;

VERSTEEGVANOOSTEN, JPM ;

POELEN, MCM ;

BRUGGHE, HF ;

HOOGERHOUT, P ;

OSTERHAUS, ADME ;

UYTDEHAAG, FGCM .

JOURNAL OF VIROLOGY, 1993, 67 (04) :2276-2284

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