Lung Cancer Mortality Mortality in the Lung Screening Study Feasibility Trial

被引：36

作者：

Doroudi, Maryam ^{[1
]}

Pinsky, Paul F. ^{[1
]}

Marcus, Pamela M. ^{[2
]}

机构：

[1] NCI, Div Canc Prevent, 9609 Med Ctr Dr, Bethesda, MD 20892 USA

[2] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

来源：

JNCI CANCER SPECTRUM | 2018年 / 2卷 / 03期

关键词：

D O I：

10.1093/jncics/pky042

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The Lung Screening Study was a multicenter controlled feasibility trial that randomly assigned subjects to undergo two rounds of screening with either low-dose spiral computed tomography (LDCT) or chest X-ray (CXR). Long-term follow-up was performed to evaluate any differences in lung-cancer-specific and all-cause mortality between arms. In 2000, subjects were randomly assigned at six screening centers. Linkage with the National Death Index was performed to ascertain long-term mortality for subjects. Median follow-up for mortality of the 1660 and 1658 subjects randomly assigned to LDCT and CXR, respectively, was 5.2 years. There were 32 and 26 deaths from lung cancer in the two groups, respectively, corresponding to lung cancer death rates of 3.84 and 3.10 per 1000 person-years, and a risk ratio of 1.24 (95% confidence interval = 0.74 to 2.08). The risk ratio for all-cause mortality was 1.20 (95% confidence interval = 0.94 to 1.54). These findings can contribute to the overall knowledge on LDCT lung cancer screening.

引用

页数：2

共 10 条

[1]

Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening [J].

Aberle, Denise R. ;

Adams, Amanda M. ;

Berg, Christine D. ;

Black, William C. ;

Clapp, Jonathan D. ;

Fagerstrom, Richard M. ;

Gareen, Ilana F. ;

Gatsonis, Constantine ;

Marcus, Pamela M. ;

Sicks, JoRean D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (05) :395-409

[2]

Baseline findings of a randomized feasibility trial of lung cancer screening with spiral CT scan vs chest radiograph - The Lung Screening Study of the National Cancer Institute [J].

Gohagan, J ;

Marcus, P ;

Fagerstrom, R ;

Pinsky, P ;

Kramer, B ;

Prorok, P .

CHEST, 2004, 126 (01) :114-121

[3]

Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer [J].

Gohagan, JK ;

Marcus, PM ;

Fagerstrom, RM ;

Pinsky, PF ;

Kramer, BS ;

Prorok, PC ;

Ascher, S ;

Bailey, W ;

Brewer, B ;

Church, T ;

Engelhard, D ;

Ford, M ;

Fouad, M ;

Freedman, M ;

Gelmann, E ;

Gierada, D ;

Hocking, W ;

Inampudi, S ;

Irons, B ;

Johnson, CC ;

Jones, A ;

Kucera, G ;

Kvale, P ;

Lappe, K ;

Manor, W ;

Moore, A ;

Nath, H ;

Neff, S ;

Oken, M ;

Plunkett, M ;

Price, H ;

Reding, D ;

Riley, T ;

Schwartz, M ;

Spizarny, D ;

Yoffie, R ;

Zylak, C .

LUNG CANCER, 2005, 47 (01) :9-15

[4]

Long-Term Follow-up Results of the DANTE Trial, a Randomized Study of Lung Cancer Screening with Spiral Computed Tomography [J].

Infante, Maurizio ;

Cavuto, Silvio ;

Lutman, Fabio Romano ;

Passera, Eliseo ;

Chiarenza, Maurizio ;

Chiesa, Giuseppe ;

Brambilla, Giorgio ;

Angeli, Enzo ;

Aranzulla, Giuseppe ;

Chiti, Arturo ;

Scorsetti, Marta ;

Navarria, Pierina ;

Cavina, Raffaele ;

Ciccarelli, Michele ;

Roncalli, Massimo ;

Destro, Anna ;

Bottoni, Edoardo ;

Voulaz, Emanuele ;

Errico, Valentina ;

Ferraroli, Giorgio ;

Finocchiaro, Giovanna ;

Toschi, Luca ;

Santoro, Armando ;

Alloisio, Marco .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 191 (10) :1166-1175

[5]

Jemal A., 2017, JNCI-J NATL CANCER I, V109, P1975, DOI DOI 10.1093/JNCI/DJX030

[6]

Mortality, survival and incidence rates in the ITALUNG randomised lung cancer screening trial [J].

Paci, Eugenio ;

Puliti, Donella ;

Pegna, Andrea Lopes ;

Carrozzi, Laura ;

Picozzi, Giulia ;

Falaschi, Fabio ;

Pistelli, Francesco ;

Aquilini, Ferruccio ;

Ocello, Cristina ;

Zappa, Marco ;

Carozzi, Francesca M. ;

Mascalchi, Mario .

THORAX, 2017, 72 (09) :825-831

[7]

Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial [J].

Pastorino, Ugo ;

Rossi, Marta ;

Rosato, Valentina ;

Marchiano, Alfonso ;

Sverzellati, Nicola ;

Morosi, Carlo ;

Fabbri, Alessandra ;

Galeone, Carlotta ;

Negri, Eva ;

Sozzi, Gabriella ;

Pelosi, Giuseppe ;

La Vecchia, Carlo .

EUROPEAN JOURNAL OF CANCER PREVENTION, 2012, 21 (03) :308-315

[8]

Projecting prostate cancer mortality in the PCPT and REDUCE chemoprevention trials [J].

Pinsky, Paul F. ;

Black, Amanda ;

Grubb, Robert ;

Crawford, E. David ;

Andriole, Gerald ;

Thompson, Ian ;

Parnes, Howard .

CANCER, 2013, 119 (03) :593-601

[9]

Results of the Randomized Danish Lung Cancer Screening Trial with Focus on High-Risk Profiling [J].

Wille, Mathilde M. W. ;

Dirksen, Asger ;

Ashraf, Haseem ;

Saghir, Zaigham ;

Bach, Karen S. ;

Brodersen, John ;

Clementsen, Paul F. ;

Nansens, Hanne ;

Larsen, Klaus R. ;

Mortensen, Jann ;

Rasmussen, Jakob F. ;

Seersholm, Niels ;

Skov, Birgit G. ;

Thomsen, Laura H. ;

Tonnesen, Philip ;

Pedersen, Jesper H. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193 (05) :542-551

[10]

Nodule management protocol of the NELSON randomised lung cancer screening trial [J].

Xu, Dong Ming ;

Gietema, Hester ;

de Koning, Harry ;

Vernhout, Rene ;

Nackaerts, Kristiaan ;

Prokop, Mathias ;

Weenink, Carla ;

Lammers, Jan-Willem ;

Groen, Harry ;

Oudkerk, Matthijs ;

van Klaveren, Rob .

LUNG CANCER, 2006, 54 (02) :177-184

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