ASYMMETRIC-SYNTHESIS OF DIFLUOROCYCLOPROPANES

被引：38

作者：

TAGUCHI, T ^{[1
]}

SHIBUYA, A ^{[1
]}

SASAKI, H ^{[1
]}

ENDO, J ^{[1
]}

MORIKAWA, T ^{[1
]}

SHIRO, M ^{[1
]}

机构：

[1] RIGAKU CORP, AKISHIMA, TOKYO 196, JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 08期

关键词：

D O I：

10.1016/0957-4166(94)80101-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A highly diastereoselective synthesis of functionalized trans gem-difluorocyclopropane carboxylate 3 was achieved through sequential Michael addition of lithium enolate of homochiral N-acylimidazolidinone 2 with 2,4,6-trimethylphenyl (TMP) 4-bromo-4,4-difluorocrotonate 1 and triethylborane-mediated intramolecular substitution reaction.

引用

页码：1423 / 1426

页数：4

共 10 条

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