NEW AND EFFICIENT COUPLING METHOD FOR THE SYNTHESIS OF PEPTIDES BEARING THE NORSTATINE RESIDUE AND THEIR ANALOGS

被引：38

作者：

OJIMA, I

SUN, CM

PARK, YH

机构：

[1] Department of Chemistry, State University of New York, New York 11794-3400, Stony Brook

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 06期

关键词：

D O I：

10.1021/jo00085a008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel ring-opening coupling reactions of enantiomerically pure (3R,4S)-1-(tert-butoxycarbonyl)-3-hydroxy beta-lactams 1 with various (S)-amino acid esters 2 including proline methyl ester proceed smoothly at ambient temperature to give the corresponding dipeptides 3 bearing the norstatine residue and its analogs in excellent yields. This new coupling method is applicable to solid-phase peptide syntheses.

引用

页码：1249 / 1250

页数：2

共 15 条

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