INDOLOCARBAZOLES .1. TOTAL SYNTHESIS AND PROTEIN-KINASE INHIBITING CHARACTERISTICS OF COMPOUNDS RELATED TO K-252C

被引：37

作者：

MCCOMBIE, SW

BISHOP, RW

CARR, D

DOBEK, E

KIRKUP, MP

KIRSCHMEIER, P

LIN, SI

PETRIN, J

ROSINSKI, K

SHANKAR, BB

WILSON, O

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07033-0539

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80013-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The condensation of indolo[2,3-a]-carbazole (12) with 2,5-dimethoxytetrahydrofuran derivatives gave cyclofuranosylated compounds (e.g. 13), which were converted via dibromocompounds to the dinitriles (e.g. 25). Hydrolysis, hydrolysis-reduction and thiolysis afforded imides, lactams (e.g. 27) and their thio analogs. These compounds were potent inhibitors of the protein kinase C family.

引用

页码：1537 / 1542

页数：6

共 36 条

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