DAILY SPONTANEOUS RUNNING ALTERS BEHAVIORAL AND NEUROCHEMICAL INDEXES OF NIGROSTRIATAL FUNCTION

被引:14
作者
DLUZEN, DE [1 ]
LIU, BJ [1 ]
CHEN, CY [1 ]
DICARLO, SE [1 ]
机构
[1] NE OHIO UNIV,COLL MED,DEPT PHYSIOL,ROOTSTOWN,OH 44272
关键词
DOPAMINE; CORPUS STRIATUM; EXERCISE; SENSORIMOTOR; SOCIAL INVESTIGATION;
D O I
10.1152/jappl.1995.78.4.1219
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Behavioral and neurochemical indexes of nigrostriatal dopaminergic function were compared between sedentary control rats (n = 12) and daily spontaneous running (DSR) male rats (n = 10). Nine weeks of DSR did not significantly alter body, heart, pituitary, or testes weights. DSR and control animals did differ in performance on a sensorimotor beam walking task, with DSR rats showing significantly shorter times required to cross the beam (60 +/- 17 vs. 119 +/- 14 s; P < 0.02) as well as fewer slips off the beam (3.0 +/- 0.8 vs. 6.2 +/- 1.1; P < 0.05). DSR animals also engaged in significantly greater durations of social investigation than control rats (43 +/- 5 vs. 25 +/- 3 s; P < 0.01) when tested in a social investigation memory-recognition test. Basal dopamine release rates from superfused corpus striatal tissue fragments of DSR rats were about one-half those obtained from control animals (18 +/- 5 vs. 34 +/- 6 pg . mg(-1). min(-1); P < 0.05), whereas responses of these striatal tissue fragments to a depolarizing concentration of potassium were virtually identical (45 +/- 10 vs. 47 +/- 8 pg . mg(-1). min(-1)). These data indicate that a relatively limited intensity of DSR insufficient to alter cardiovascular function can exert substantial effects on behavioral and neurochemical indicators of nigrostriatal dopaminergic activity.
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页码:1219 / 1224
页数:6
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