REGIONAL EFFECTS OF MK-801 ON DOPAMINE AND ITS METABOLITES STUDIED BY INVIVO MICRODIALYSIS

被引：64

作者：

WHITTON, PS

BIGGS, CS

PEARCE, BR

FOWLER, LJ

机构：

[1] Department of Pharmacology, The School of Pharmacy, London

来源：

NEUROSCIENCE LETTERS | 1992年 / 142卷 / 01期

关键词：

DOPAMINE; MK-801; MICRODIALYSIS; ANTERIOR STRIATUM; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(92)90607-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The non-competitive N-methyl-D-aspartate receptor antagonist MK-801 was observed to have regionally specific effects on the extracellular concentration of dopamine and its metabolites. In rat anterior striatum, MK-801 transiently decreased extracellular dopamine, in spite of inducing intense circling behaviour which is generally associated with an increase in this neurotransmitter. In contrast, hippocampal extracellular dopamine was increased in a dose-related manner by MK-801. The possible significance of these data is discussed in relation to some of the known behavioural actions of MK-801.

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页码：5 / 8

页数：4

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