DESIGN AND OPTIMIZATION OF THE VARIABLES IN THE ADSORPTIVE STRIPPING VOLTAMMETRIC DETERMINATION OF RUFLOXACIN IN TABLETS, HUMAN PLASMA AND URINE

被引：27

作者：

FURLANETTO, S

GRATTERI, P

PINZAUTI, S

LEARDI, R

DREASSI, E

SANTONI, G

机构：

[1] GENET UNIT,IST ANAL & TECNOL FARMACEUT & ALIMENTARI,I-16147 GENOA,ITALY

[2] UNIV SIENA,DIPARTIMENTO FARMACO CHIM TECNOL,I-53100 SIENA,ITALY

[3] STABILIMENTO CHIM FARMACEUT MIL,I-50141 FLORENCE,ITALY

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1995年 / 13卷 / 4-5期

关键词：

ADSORPTIVE STRIPPING VOLTAMMETRY; RUFLOXACIN; HUMAN PLASMA AND URINE ANALYSIS; EXPERIMENTAL DESIGN; REGRESSION MODELING; RESPONSE SURFACE PLOT; HPLC DETERMINATION;

D O I：

10.1016/0731-7085(95)01288-V

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An adsorptive stripping voltammetric method with a hanging mercury drop electrode was developed for the determination of the fluoroquinolone rufloxacin in tablets, human plasma and urine. Measurements were obtained in differential pulse mode and a multivariate strategy was used to optimize the variables involved. Besides the independent effects of the variables, a strong interaction between scan rate and pulse duration has been found. Rufloxacin was analysed at concentrations between 1.7 x 10(-8) and 1.9 x 10(-7) M with a detection limit of 9.2 x 10(-9) M. Diluted tablet solutions and urine samples were analysed directly, while plasma samples needed an extraction procedure before voltammetric analysis. An improved HPLC procedure was used as comparative method.

引用

页码：431 / 438

页数：8

共 11 条

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