NEWS FROM THE INTERFACE - THE MOLECULAR-STRUCTURES OF TRIACYLGLYCERIDE LIPASES

被引：186

作者：

DEREWENDA, ZS

SHARP, AM

机构：

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0968-0004(93)90082-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutral lipases constitute one of the most ubiquitous and diverse families of enzymes. The recently solved crystal structures of three lipases show that enzymatic hydrolysis occurs with the assistance of a catalytic triad, which is structurally reminiscent of serine proteinases. However, these lipases only become active at the oil-water interface through a conformational change that exposes the active centre of the enzyme.

引用

页码：20 / 25

页数：6

共 32 条

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