3'-DEMETHOXY-3'-HYDROXYSTAUROSPORINE, A NOVEL STAUROSPORINE ANALOG PRODUCED BY A BLOCKED MUTANT

被引：22

作者：

HOEHN, P

GHISALBA, O

MOERKER, T

PETER, HH

机构：

[1] Sandoz Ltd.

[2] Pharmaceutical Research Department, Microbial Chemistry, CIBA-GEIGY Ltd.

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 04期

关键词：

D O I：

10.7164/antibiotics.48.300

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

3'-Demethoxy-3'-hydroxystaurosporine, 1 (CGP 58 546), a novel staurosporine analogue, was isolated from a mutant of Streptomyces longisporoflavus R19 blocked in the last step of the biosynthetic pathway. CGP 58 546 was less potent than staurosporine, but it showed a more selective inhibition pattern against various subtypes of protein kinase C.

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页码：300 / 305

页数：6

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