Sex and Gender Differences in Non-Small Cell Lung Cancer

被引：63

作者：

Donington, Jessica S. ^{[1
]}

Colson, Yolonda L. ^{[2
]}

机构：

[1] NYU, Sch Med, Dept Cardiothorac Surg, 530 1st Ave,Suite 9V, New York, NY 10016 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Div Thorac Surg, Womens Lung Canc Program, Boston, MA USA

来源：

SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY | 2011年 / 23卷 / 02期

关键词：

non-small cell lung carcinoma; gender; epidemiology; prognosis; tobacco; estrogen;

D O I：

10.1053/j.semtcvs.2011.07.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Historically, lung cancer has been viewed as a male disease, but during the past 50 years there has been a dramatic increase in the incidence of lung cancer in women. Lung cancer is currently the most common cause of cancer death in American women, accounting for more than one quarter of all cancer deaths. This has been attributed to a significant increase in tobacco consumption by women; however, approximately 1 in 5 women with lung cancer never smoked. As the incidence of lung cancer in women has increased, significant gender-based differences in epidemiology, biology, and treatment responses have become evident and warrant further investigation to advance the treatment of lung cancer in all patients. © 2011 Elsevier Inc.

引用

页码：137 / 145

页数：9

共 97 条

[31] Women's susceptibility to tobacco carcinogens [J].

Henschke, CI ;

Miettinen, OS .

LUNG CANCER, 2004, 43 (01) :1-5

[32] High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan [J].

Huang, SF ;

Liu, HP ;

Li, LH ;

Ku, YC ;

Fu, YN ;

Tsai, HY ;

Chen, YT ;

Lin, YF ;

Chang, WC ;

Kuo, HP ;

Wu, YC ;

Chen, YR ;

Tsai, SF .

CLINICAL CANCER RESEARCH, 2004, 10 (24) :8195-8203

[33] Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol [J].

IgnarTrowbridge, DM ;

Pimentel, M ;

Parker, MG ;

McLachlan, JA ;

Korach, KS .

ENDOCRINOLOGY, 1996, 137 (05) :1735-1744

[34]

Jemal A, 2011, CA-CANCER J CLIN, V61, P133, DOI [10.3322/caac.20105, 10.3322/caac.20073]

[35] Annual Report to the Nation on the Status of Cancer, 1975-2005, Featuring Trends in Lung Cancer, Tobacco Use, and Tobacco Control [J].

Jemal, Ahmedin ;

Thun, Michael J. ;

Ries, Lynn A. G. ;

Howe, Holly L. ;

Weir, Hannah K. ;

Center, Melissa M. ;

Ward, Elizabeth ;

Wu, Xiao-Cheng ;

Eheman, Christie ;

Anderson, Robert ;

Ajani, Umed A. ;

Kohler, Betsy ;

Edwards, Brenda K. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (23) :1672-1694

[36] Estrogen receptor α and β are prognostic factors in non-small cell lung cancer [J].

Kawai, H ;

Ishii, A ;

Washiya, K ;

Konno, T ;

Kon, H ;

Yamaya, C ;

Ono, I ;

Minamiya, Y ;

Ogawa, J .

CLINICAL CANCER RESEARCH, 2005, 11 (14) :5084-5089

[37] The influence of gender on survival and tumor recurrence following adjuvant therapy of completely resected stages II and IIIa non-small cell lung cancer [J].

Keller, SM ;

Vangel, MG ;

Adak, S ;

Wagner, H ;

Schiller, JH ;

Herskovic, A ;

Komaki, R ;

Perry, MC ;

Marks, RS ;

Livingston, RB ;

Johnson, DH .

LUNG CANCER, 2002, 37 (03) :303-309

[38] Do men outperform women in smoking cessation trials? Maybe, but not by much [J].

Killen, JD ;

Fortmann, SP ;

Varady, A ;

Kraemer, HC .

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 2002, 10 (03) :295-301

[39] Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer - A randomized trial [J].

Kris, MG ;

Natale, RB ;

Herbst, RS ;

Lynch, TJ ;

Prager, D ;

Belani, CP ;

Schiller, JH ;

Kelly, K ;

Spiridonidis, H ;

Sandler, A ;

Albain, KS ;

Cella, D ;

Wolf, MK ;

Averbuch, SD ;

Ochs, JJ ;

Kay, AC .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (16) :2149-2158

[40] P53 mutations in lung tumours: Relationship to gender and lung DNA adduct levels [J].

Kure, EH ;

Ryberg, D ;

Hewer, A ;

Phillips, DH ;

Skaug, V ;

Baera, R ;

Haugen, A .

CARCINOGENESIS, 1996, 17 (10) :2201-2205

← 1 2 3 4 5 6 7 8 9 10 →