HYPERPHAGIA FOLLOWING INTRA-VENTRICULAR PARA-CHLOROPHENYLALANINE-METHYL, LEUCINE-METHYL OR TRYPTOPHAN-METHYL ESTERS - LACK OF CORRELATION WITH WHOLE BRAIN-SEROTONIN LEVELS

被引：24

作者：

MACKENZIE, RG ^{[1
]}

HOEBEL, BG ^{[1
]}

DUCRET, RP ^{[1
]}

TRULSON, ME ^{[1
]}

机构：

[1] PRINCETON UNIV,DEPT PSYCHOL,PROGRAM NEUROSCI,PRINCETON,NJ 08540

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 06期

关键词：

Hyperphagia; Leucine; p-Chlorophenylalanine; Serotonin; Tryptophan;

D O I：

10.1016/0091-3057(79)90075-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The methyl ester hydrochlorides of DL-p-chlorophenylalanine (PCPA), L-leucine and L-tryptophan were intraventricularly administered to rats. All compounds produced increased food intake compared to saline administration. PCPA and leucine administration significantly decreased serotonin levels by 15-18%, while no serotonin depletion occurred following tryptophan injections. The data suggest that intraventricular injections of large quantities of neutral amino acid methyl esters may cause hyperphagia in rats through non-serotonergic effects on brain function. © 1979.

引用

页码：951 / 955

页数：5

共 24 条

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