HYPERPHAGIA FOLLOWING INTRA-VENTRICULAR PARA-CHLOROPHENYLALANINE-METHYL, LEUCINE-METHYL OR TRYPTOPHAN-METHYL ESTERS - LACK OF CORRELATION WITH WHOLE BRAIN-SEROTONIN LEVELS

被引：24

作者：

MACKENZIE, RG ^{[1
]}

HOEBEL, BG ^{[1
]}

DUCRET, RP ^{[1
]}

TRULSON, ME ^{[1
]}

机构：

[1] PRINCETON UNIV,DEPT PSYCHOL,PROGRAM NEUROSCI,PRINCETON,NJ 08540

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 06期

关键词：

Hyperphagia; Leucine; p-Chlorophenylalanine; Serotonin; Tryptophan;

D O I：

10.1016/0091-3057(79)90075-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The methyl ester hydrochlorides of DL-p-chlorophenylalanine (PCPA), L-leucine and L-tryptophan were intraventricularly administered to rats. All compounds produced increased food intake compared to saline administration. PCPA and leucine administration significantly decreased serotonin levels by 15-18%, while no serotonin depletion occurred following tryptophan injections. The data suggest that intraventricular injections of large quantities of neutral amino acid methyl esters may cause hyperphagia in rats through non-serotonergic effects on brain function. © 1979.

引用

页码：951 / 955

页数：5

共 24 条

[11] HOEBEL BG, 1978, ANN NY ACAD SCI, V308, P590
[12] HOEBEL BG, 1977, HDB PSYCHOPHARMACOLO, P55
[13] ROLES OF MONOAMINE NEURAL SYSTEMS IN ANOREXIA INDUCED BY (+)-AMPHETAMINE AND RELATED COMPOUNDS
HOLLISTER, AS
ERVIN, GN
COOPER, BR
BREESE, GR
[J]. NEUROPHARMACOLOGY, 1975, 14 (10) : 715 - 723
[14] METHOD FOR RAPID-DETERMINATION OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN IN SAME BRAIN REGION
JACOBOWITZ, DM
RICHARDSON, JS
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1978, 8 (05) : 515 - 519
[15] EVIDENCE FOR A DIFFERENCE IN MECHANISM OF ACTION BETWEEN FENFLURAMINE-INDUCED AND AMPHETAMINE-INDUCED ANOREXIA
JESPERSEN, S
SCHEELKR.J
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1973, 25 (01) : 49 - 54
[16] KOE BK, 1966, J PHARMACOL EXP THER, V154, P499
[17] STUDIES ON BEHAVIOURAL AND BIOCHEMICAL CHANGES IN RATS AFTER LESION OF MIDBRAIN RAPHE
KOSTOWSKI, W
GIACALONE, E
GARATTINI, S
VALZELLI, L
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1968, 4 (04) : 371 - +
[18] MYERS RD, 1978, ANN NY ACAD SCI, V308, P556
[19] SALLER CF, 1976, SCIENCE, V192, P385, DOI 10.1126/science.1257774
[20] DECREASE OF FOOD-INTAKE BY QUIPAZINE IN RAT - RELATION TO SEROTONINERGIC RECEPTOR STIMULATION
SAMANIN, R
BENDOTTI, C
MIRANDA, F
GARATTINI, S
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1977, 29 (01) : 53 - 54

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