HYPERPHAGIA FOLLOWING INTRA-VENTRICULAR PARA-CHLOROPHENYLALANINE-METHYL, LEUCINE-METHYL OR TRYPTOPHAN-METHYL ESTERS - LACK OF CORRELATION WITH WHOLE BRAIN-SEROTONIN LEVELS

被引：24

作者：

MACKENZIE, RG ^{[1
]}

HOEBEL, BG ^{[1
]}

DUCRET, RP ^{[1
]}

TRULSON, ME ^{[1
]}

机构：

[1] PRINCETON UNIV,DEPT PSYCHOL,PROGRAM NEUROSCI,PRINCETON,NJ 08540

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 06期

关键词：

Hyperphagia; Leucine; p-Chlorophenylalanine; Serotonin; Tryptophan;

D O I：

10.1016/0091-3057(79)90075-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The methyl ester hydrochlorides of DL-p-chlorophenylalanine (PCPA), L-leucine and L-tryptophan were intraventricularly administered to rats. All compounds produced increased food intake compared to saline administration. PCPA and leucine administration significantly decreased serotonin levels by 15-18%, while no serotonin depletion occurred following tryptophan injections. The data suggest that intraventricular injections of large quantities of neutral amino acid methyl esters may cause hyperphagia in rats through non-serotonergic effects on brain function. © 1979.

引用

页码：951 / 955

页数：5

共 24 条

[21] EFFECTS OF SELECTIVE LESIONING OF BRAIN-SEROTONIN OR CATECHOLAMINE CONTAINING NEURONS ON ANORECTIC ACTIVITY OF FENFLURAMINE AND AMPHETAMINE
SAMANIN, R
VALZELLI, L
GARATTINI, S
GHEZZI, D
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1972, 19 (03) : 318 - +
[22] BEHAVIORAL-EFFECTS OF SELECTIVE MIDBRAIN RAPHE LESIONS IN RAT
SREBRO, B
LORENS, SA
[J]. BRAIN RESEARCH, 1975, 89 (02) : 303 - 325
[23] FAILURE OF DEPLETION OF RAT-BRAIN 5-HYDROXYTRYPTAMINE TO ALTER FENFLURAMINE-INDUCED ANOREXIA
SUGRUE, MF
GOODLET, I
MCINDEWAR, I
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1975, 27 (12) : 950 - 953
[24] FAILURE OF TRYPTOPHAN LOAD-INDUCED INCREASES IN BRAIN-SEROTONIN TO ALTER FOOD-INTAKE IN RAT
WEINBERGER, SB
KNAPP, S
MANDELL, AJ
[J]. LIFE SCIENCES, 1978, 22 (18) : 1595 - 1602

← 1 2 3 →