BIOSYNTHESIS OF VITAMIN-B12 - STEREOCHEMISTRY OF TRANSFER OF A HYDRIDE EQUIVALENT FROM NADPH BY PRECORRIN-6X REDUCTASE

被引：14

作者：

KIUCHI, F

THIBAUT, D

DEBUSSCHE, L

LEEPER, FJ

BLANCHE, F

BATTERSBY, AR

机构：

[1] UNIV CAMBRIDGE,CHEM LAB,LENSFIELD RD,CAMBRIDGE CB2 1EW,ENGLAND

[2] CTR RECH VITRY ALFORTVILLE,DEPT ANAL,F-94403 VITRY,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 04期

关键词：

D O I：

10.1039/c39920000306

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Deuterium labelling with NMR analysis demonstrates that the enzyme precorrin-6x reductase transfers H(R) from C-4 of the pyridine residue of NADPH as the first step in the sequence leading from precorrin-6x to hydrogenobyrinic acid.

引用

页码：306 / 308

页数：3

共 10 条

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