ENANTIOSELECTIVE SYNTHESIS OF GIROLLINE

被引：23

作者：

COMMERCON, A

PARIS, JM

机构：

[1] Rhône-Poulenc Rorer - Centre de Recherches de Vitry-Alfortville 13, 94403 Vitry-sur-Seine

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(00)93492-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Girolline (RP 49532) is efficiently and enantioselectively synthesized from the aldol reaction of (R)-3-chloroacetyl-4-isopropyl-1,3-oxazolidin-2-one 2 and 1-triphenylmethylimidazole-4-carboxaldehyde 3 followed by reaction with aqueous ammonia and reduction with borane. The last steps use the 2-arylazo procedure.

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页码：4905 / 4906

页数：2

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