RECRUITMENT OF SUBSTRATE-SPECIFICITY PROPERTIES FROM ONE ENZYME INTO A RELATED ONE BY PROTEIN ENGINEERING

被引：148

作者：

WELLS, JA ^{[1
]}

CUNNINGHAM, BC ^{[1
]}

GRAYCAR, TP ^{[1
]}

ESTELL, DA ^{[1
]}

机构：

[1] GENECOR INC,RES DEPT,S SAN FRANCISCO,CA 94080

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1987年 / 84卷 / 15期

关键词：

D O I：

10.1073/pnas.84.15.5167

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：5167 / 5171

页数：5

共 40 条

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[6] REDESIGNING TRYPSIN - ALTERATION OF SUBSTRATE-SPECIFICITY
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[7] ESTELL DA, 1985, J BIOL CHEM, V260, P6518
[8] PROBING STERIC AND HYDROPHOBIC EFFECTS ON ENZYME-SUBSTRATE INTERACTIONS BY PROTEIN ENGINEERING
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[J]. SCIENCE, 1986, 233 (4764) : 659 - 663
[9] HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING
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[J]. NATURE, 1985, 314 (6008) : 235 - 238
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