RETINOID X-RECEPTOR IS AN AUXILIARY PROTEIN FOR THYROID-HORMONE AND RETINOIC ACID RECEPTORS

被引：926

作者：

ZHANG, XK ^{[1
]}

HOFFMANN, B ^{[1
]}

TRAN, PBV ^{[1
]}

GRAUPNER, G ^{[1
]}

PFAHL, M ^{[1
]}

机构：

[1] LA JOLLA CANC RES FDN,CTR CANC,LA JOLLA,CA 92037

来源：

NATURE | 1992年 / 355卷 / 6359期

关键词：

D O I：

10.1038/355441a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THYROID hormones and retinoic acid function through nuclear receptors that belong to the steroid/thyroid-hormone receptor superfamily (reviewed in refs 1-4). Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) require auxiliary nuclear proteins for efficient DNA binding 5-10. Here we report that retinoid X receptors RXR-alpha (ref. 11) is one of these nuclear proteins. RXR-alpha interacts both with TRs and with RARs, forming heterodimers in solution that strongly interact with a variety of T3/retinoic acid response elements. Transfection experiments show that RXR-alpha can greatly enhance the transcriptional activity of TR and RAR at low retinoic acid concentrations that do not significantly activate RXR-alpha itself. Thus, RXR-alpha enhances the transcriptional activity of other receptors and its own ligand sensitivity by heterodimer formation. Our studies reveal a new subclass of receptors and a regulatory pathway controlling nuclear receptor activities by heterodimer formation.

引用

页码：441 / 446

页数：6

共 29 条

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