X-RAY-ANALYSIS OF 2',3'-LYXOANHYDROTHYMIDINE, A CONFORMATIONALLY RESTRICTED INHIBITOR OF RETROVIRAL REVERSE TRANSCRIPTASES

被引：20

作者：

GURSKAYA, GV ^{[1
]}

BOCHKAREV, AV ^{[1
]}

ZDANOV, AS ^{[1
]}

PAPCHIKHIN, AV ^{[1
]}

PURYGIN, PP ^{[1
]}

KRAYEVSKY, AA ^{[1
]}

机构：

[1] KUYBYSHEV STATE UNIV,KUYBYSHEV 443086,USSR

来源：

FEBS LETTERS | 1990年 / 265卷 / 1-2期

关键词：

2'; 3'-Lyxoanhydrothymidine; DNA biosynthesis; Reverse transcriptase; X-ray analysis;

D O I：

10.1016/0014-5793(90)80884-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2',3'-Lyxoanhydrothymidine (LAT), a conformationally restricted inhibitor of retroviral reverse transcriptases, has been studied by X-ray analysis. The unit cell contains two crystallographically independent molecules A and B. Their sugar moieties have an identical structure: an 04'-endo pucker of the furanose cycle and a trans conformation about the exocyclic C4'-C5' bond. The conformations of A and B molecules differ with respect to the N-glycosidic bond: χA(04 'Cl' N1C2) = -121.9° which is typical of a common anti conformation whereas χB (04'Cl'N1C2) = 121.2° corresponds to a rare high-syn conformation. All the conformation properties of LAT molecules stem from the presence of an epoxide cycle in their molecules. © 1990.

引用

页码：63 / 66

页数：4

共 15 条

[1] CONFORMATIONAL-ANALYSIS OF SUGAR RING IN NUCLEOSIDES AND NUCLEOTIDES - NEW DESCRIPTION USING CONCEPT OF PSEUDOROTATION [J].