GENETIC-DETERMINANTS OF TESTIS DEVELOPMENT IN NORMAL AND ABNORMAL INDIVIDUALS

被引：1

作者：

HAWKINS, JR

机构：

[1] Imperial Cancer Research Fund, London

来源：

HORMONE RESEARCH | 1992年 / 38卷

关键词：

SRY; TDF; TESTIS DETERMINATION; XX MALES; XY FEMALES;

D O I：

10.1159/000182599

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A candidate for the male sex determining gene 2 has recently been isolated. This gene, named SRY, has an expression profile consistent with a role in testis determination, is mutated in some XY females, and causes female to male sex reversal in transgenic mice. The cloning of this gene should facilitate the characterization of other genes in the testis determining pathway.

引用

页码：62 / 65

页数：4

共 9 条

[1] GENETIC-EVIDENCE EQUATING SRY AND THE TESTIS-DETERMINING FACTOR [J].

BERTA, P ;

HAWKINS, JR ;

SINCLAIR, AH ;

TAYLOR, A ;

GRIFFITHS, BL ;

GOODFELLOW, PN ;

FELLOUS, M .

NATURE, 1990, 348 (6300) :448-450

[2]

FORD CE, 1959, LANCET, V1, P711

[3]

HARLEY VR, IN PRESS SCIENCE

[4]

JACOBS PA, 1959, NATURE, V183, P320

[5]

Jost A., 1973, Recent Progress Hormone Res, V29, P1

[6] MALE DEVELOPMENT OF CHROMOSOMALLY FEMALE MICE TRANSGENIC FOR SRY [J].

KOOPMAN, P ;

GUBBAY, J ;

VIVIAN, N ;

GOODFELLOW, P ;

LOVELLBADGE, R .

NATURE, 1991, 351 (6322) :117-121

[7] EXPRESSION OF A CANDIDATE SEX-DETERMINING GENE DURING MOUSE TESTIS DIFFERENTIATION [J].

KOOPMAN, P ;

MUNSTERBERG, A ;

CAPEL, B ;

VIVIAN, N ;

LOVELLBADGE, R .

NATURE, 1990, 348 (6300) :450-452

[8]

MCELREAVEY K, 1991, CYTOGENET CELL GENET, V58, P2093

[9] A GENE FROM THE HUMAN SEX-DETERMINING REGION ENCODES A PROTEIN WITH HOMOLOGY TO A CONSERVED DNA-BINDING MOTIF [J].

SINCLAIR, AH ;

BERTA, P ;

PALMER, MS ;

HAWKINS, JR ;

GRIFFITHS, BL ;

SMITH, MJ ;

FOSTER, JW ;

FRISCHAUF, AM ;

LOVELLBADGE, R ;

GOODFELLOW, PN .

NATURE, 1990, 346 (6281) :240-244

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