INCORPORATION OF 6-THIOINOSINE INTO OLIGORIBONUCLEOTIDES

被引:7
作者
ADAMS, CJ [1 ]
FARROW, MA [1 ]
MURRAY, JB [1 ]
KELLY, SM [1 ]
PRICE, NC [1 ]
STOCKLEY, PG [1 ]
机构
[1] UNIV STIRLING,DEPT BIOL & MOLEC SCI,STIRLING FK9 4LA,SCOTLAND
关键词
D O I
10.1016/0040-4039(95)00805-M
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Preparation of S-6-cyanoethyl-6-thioinosine and its incorporation into oligoribonucleotides, using standard phosphoramidite methods, is described. Evidence for binding between the minimal RNA recognition sequence (minSLIIB) and the cognate HIV-1-GST-Rev protein was obtained from the changes in the unique circular dichroism band at 320 nm of 6-thioinosine.
引用
收藏
页码:4637 / 4640
页数:4
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