SPECIFYING THE TARGET IDENTITY OF MOTONEURONS

被引：27

作者：

TOSNEY, KW ^{[1
]}

HOTARY, KB ^{[1
]}

LANCEJONES, C ^{[1
]}

机构：

[1] UNIV PITTSBURGH,SCH MED,DEPT NEUROBIOL,PITTSBURGH,PA 15261

来源：

BIOESSAYS | 1995年 / 17卷 / 05期

关键词：

D O I：

10.1002/bies.950170503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the vertebrate spinal cord, motoneurons are clustered into longitudinal columns in agreement with the targets they innervate. Motoneurons within each column acquire properties early in development that ensure their axons navigate to appropriate targets, but how this target identity is specified is unknown. Recently, Tsuchida et al.((1)) described the expression of putative regulatory genes within motor columns in the chicken spinal cord. Combinations of LIM-family homeobox genes differentially mark columns that project to distinct target groups. Expression precedes column formation and axon outgrowth, making these genes candidates for specifying the target identity of motoneuron groups.

引用

页码：379 / 382

页数：4

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