NOVEL SYNTHESIS OF APORPHINES VIA 3-PHENYLPHENETHYLAMINES

被引:9
作者
GERECKE, M
BROSSI, A
机构
[1] Pharmaceutical Research Department, F. Hoffmann-La Roche & Co. Ltd., Basel
[2] Section of Medicinal Chemistry, Niamdd, National Institutes of Health, Bethesda, Maryland
关键词
D O I
10.1002/hlca.19790620520
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
rac‐1,2,10‐Trimethoxy‐aporphine (14) and rac‐2‐ethoxy‐10,11‐dimethoxyaporphine (27) have been synthesized from the 3‐phenylphenethylamines 9 and 22 by a new route. The 8‐phenyl‐3,4‐dihydroisoquinolines 11 and 24, the oxo‐aporphines 12 and 25 and the rac‐nor‐aporphines 13 and 26 were obtained as intermediates. Copyright © 1979 Verlag GmbH & Co. KGaA, Weinheim
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页码:1549 / 1558
页数:10
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