ANTITUMOR AGENTS .136. CUMINGIANOSIDES A-F, POTENT ANTILEUKEMIC NEW TRITERPENE GLUCOSIDES, AND CUMINDYSOSIDE-A AND CUMINDYSOSIDE-B, TRISNORTRITERPENE AND TETRANORTRITERPENE GLUCOSIDES WITH A 14,18-CYCLOAPOEUPHANE-TYPE SKELETON FROM DYSOXYLUM-CUMINGIANUM

被引：43

作者：

KASHIWADA, Y

FUJIOKA, T

CHANG, JJ

CHEN, IS

MIHASHI, K

LEE, KH

机构：

[1] UNIV N CAROLINA, SCH PHARM, DIV MED CHEM & NAT PROD, NAT PROD LAB, CHAPEL HILL, NC 27599 USA

[2] KAOHSIUNG MED COLL, NAT PROD RES CTR, KAOHSIUNG, TAIWAN

[3] FUKUOKA UNIV, FAC PHARMACEUT SCI, FUKUOKA 81401, JAPAN

[4] UNIV N CAROLINA, SCH MED, DEPT PATHOL, CHAPEL HILL, NC 27599 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 25期

关键词：

D O I：

10.1021/jo00051a050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six new triterpene glucosides, cumingianosides A-F (1-6) as well as a trisnor- and a tetranortriterpene glucoside, cumindysosides A (7) and B (8), respectively, with a 14,18-cycloapoeuphane-type skeleton have been isolated from Dysoxylum cumingianum as antileukemic principles. The structures were established on the basis of chemical and spectroscopic evidence. Among them, compounds 1 and 3 exhibited potent selective cytotoxicity against MOLT-4 human leukemia cell with ED50 of <0.006 25 and <0.0045 mug/mL, respectively.

引用

页码：6946 / 6953

页数：8

共 12 条

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[12] ANTITUMOR AGENTS .135. STRUCTURE AND STEREOCHEMISTRY OF POLACANDRIN, A NEW CYTOTOXIC TRITERPENE FROM POLANISIA-DODECANDRA [J].

SHI, Q ;

CHEN, K ;

FUJIOKA, T ;

KASHIWADA, Y ;

CHANG, JJ ;

KOZUKA, M ;

ESTES, JR ;

MCPHAIL, AT ;

MCPHAIL, DR ;

LEE, KH .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (10) :1488-1497

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