CHOLECYSTOKININ ANTAGONISTS - SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-SUBSTITUTED 4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPINES

被引：24

作者：

BOCK, MG ^{[1
]}

DIPARDO, RM ^{[1
]}

EVANS, BE ^{[1
]}

RITTLE, KE ^{[1
]}

VEBER, DF ^{[1
]}

FREIDINGER, RM ^{[1
]}

CHANG, RSL ^{[1
]}

LOTTI, VJ ^{[1
]}

机构：

[1] MERCK SHARP & DOHME RES LABS,DEPT MICROBIAL PHARMACOMETR,W POINT,PA 19486

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 01期

关键词：

D O I：

10.1021/jm00396a028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：176 / 181

页数：6

共 34 条

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[2] THE DISTRIBUTION OF CHOLECYSTOKININ IMMUNOREACTIVITY IN THE CENTRAL NERVOUS-SYSTEM OF THE RAT AS DETERMINED BY RADIOIMMUNOASSAY
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MEYER, DK
ESKAY, RL
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[3] AN EXPEDIENT SYNTHESIS OF 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE
BOCK, MG
DIPARDO, RM
EVANS, BE
RITTLE, KE
VEBER, DF
FREIDINGER, RM
[J]. TETRAHEDRON LETTERS, 1987, 28 (09) : 939 - 942
[4] UBER ALPHA-HALOGENIERTE AMINE .8. UBER DIE SPALTUNG VON AMINALEN UND ALPHA-DIALKYLAMINO-ATHERN MIT CARBONSAUREHALOGENIDEN
BOHME, H
HARTKE, K
[J]. CHEMISCHE BERICHTE-RECUEIL, 1960, 93 (06): : 1305 - 1309
[5] BENZODIAZEPINES ANTAGONIZE CHOLECYSTOKININ-INDUCED ACTIVATION OF RAT HIPPOCAMPAL-NEURONS
BRADWEJN, J
DEMONTIGNY, C
[J]. NATURE, 1984, 312 (5992) : 363 - 364
[6] ANTAGONISM OF CHOLECYSTOKININ-INDUCED ACTIVATION BY BENZODIAZEPINE RECEPTOR AGONISTS - MICROIONTOPHORETIC STUDIES IN THE RAT HIPPOCAMPUS
BRADWEJN, J
DEMONTIGNY, C
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 448 (JUL) : 575 - 580
[7] INCREASE IN BRAIN I-125-LABELED CHOLECYSTOKININ (CCK) RECEPTOR-BINDING FOLLOWING CHRONIC HALOPERIDOL TREATMENT, INTRACISTERNAL 6-HYDROXYDOPAMINE OR VENTRAL TEGMENTAL LESIONS
CHANG, RSL
LOTTI, VJ
MARTIN, GE
CHEN, TB
[J]. LIFE SCIENCES, 1983, 32 (08) : 871 - 878
[8] BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF AN EXTREMELY POTENT AND SELECTIVE NONPEPTIDE CHOLECYSTOKININ ANTAGONIST
CHANG, RSL
LOTTI, VJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) : 4923 - 4926
[9] A POTENT NONPEPTIDE CHOLECYSTOKININ ANTAGONIST SELECTIVE FOR PERIPHERAL-TISSUES ISOLATED FROM ASPERGILLUS-ALLIACEUS
CHANG, RSL
LOTTI, VJ
MONAGHAN, RL
BIRNBAUM, J
STAPLEY, EO
GOETZ, MA
ALBERSSCHONBERG, G
PATCHETT, AA
LIESCH, JM
HENSENS, OD
SPRINGER, JP
[J]. SCIENCE, 1985, 230 (4722) : 177 - 179
[10] ISOLATION, STRUCTURE AND BIOLOGICAL-ACTIVITY OF 2 CHOLECYSTOKININ OCTAPEPTIDES FROM SHEEP BRAIN
DOCKRAY, GJ
GREGORY, RA
HUTCHISON, JB
HARRIS, JI
RUNSWICK, MJ
[J]. NATURE, 1978, 274 (5672) : 711 - 713

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