CURCUMIN INHIBITS IRON-DEPENDENT LIPID-PEROXIDATION

被引：33

作者：

SREEJAYAN ^{[1
]}

RAO, MNA ^{[1
]}

机构：

[1] COLL PHARMACEUT SCI,DEPT PHARMACEUT CHEM,MANIPAL 576119,INDIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 100卷 / 1-3期

关键词：

CURCUMIN; IRON; LIPID PEROXIDATION;

D O I：

10.1016/0378-5173(93)90079-U

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Curcumin inhibited lipid peroxidation induced by ferric ions, ferrous ions and ferric-ADP chelate (in the presence of ascorbic acid or NADPH) in rat brain homogenate and liver microsomes. This may represent one of the mechanisms through which curcumin exhibits anti-inflammatory and anticancer activities.

引用

页码：93 / 97

页数：5

共 24 条

[11] EFFECT OF CURCUMIN ON HYDROXYL RADICAL GENERATION THROUGH FENTON REACTION [J].

KUNCHANDY, E ;

RAO, MNA .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1989, 57 (02) :173-176

[12]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[13]

MINOTTI G, 1987, J BIOL CHEM, V262, P1098

[14] THE ROLE OF AN ENDOGENOUS NONHEME IRON IN MICROSOMAL REDOX REACTIONS [J].

MINOTTI, G .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 297 (02) :189-198

[15]

PABON HJJ, 1964, RECL TRAV CHIM PAY B, V83, P379

[16] ANTIOXIDANT ACTIVITY OF CURCUMIN AND RELATED COMPOUNDS [J].

SHARMA, OP .

BIOCHEMICAL PHARMACOLOGY, 1976, 25 (15) :1811-1812

[17] LIPID PEROXIDE FORMATION IN EXPERIMENTAL INFLAMMATION [J].

SHARMA, SC ;

SHARMA, SK ;

MURT, CRK ;

MUKHTAR, H .

BIOCHEMICAL PHARMACOLOGY, 1972, 21 (08) :1210-&

[18]

SRIMAL R C, 1987, Drugs of the Future, V12, P331

[19] ESTROGENS AS NATURAL ANTIOXIDANTS OF MEMBRANE PHOSPHOLIPID PEROXIDATION [J].

SUGIOKA, K ;

SHIMOSEGAWA, Y ;

NAKANO, M .

FEBS LETTERS, 1987, 210 (01) :37-39

[20]

SUSAN M, 1992, ARZNEIMITTEL-FORSCH, V42-2, P962

← 1 2 3 →