SPIRONOLACTONE METABOLISM - STEADY-STATE SERUM LEVELS OF THE SULFUR-CONTAINING METABOLITES

被引：106

作者：

GARDINER, P

SCHRODE, K

QUINLAN, D

MARTIN, BK

BOREHAM, DR

ROGERS, MS

STUBBS, K

SMITH, M

KARIM, A

机构：

[1] GD SEARLE & CO LTD,SEARLE RES & DEV,HIGH WYCOMBE HP12 4HL,BUCKS,ENGLAND

[2] BIOS CONSULTANCY & CONTRACT RES LTD,BAGSHOT,ENGLAND

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1989年 / 29卷 / 04期

关键词：

D O I：

10.1002/j.1552-4604.1989.tb03339.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：342 / 347

页数：6

共 12 条

[1] KINETICS OF CANRENONE AFTER SINGLE AND MULTIPLE DOSES OF SPIRONOLACTONE [J].

ABSHAGEN, U ;

BESENFELDER, E ;

ENDELE, R ;

KOCH, K ;

NEUBERT, B .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (04) :255-262

[2]

ABSHAGEN U, 1976, N-S ARCH PHARMACOL, V296, P37, DOI 10.1007/BF00498838

[3]

DAHLOF CG, 1979, DRUG METAB DISPOS, V7, P103

[4] MOLECULAR MODIFICATIONS OF ANTI-ALDOSTERONE COMPOUNDS - EFFECTS ON AFFINITY OF SPIRONOLACTONES FOR RENAL ALDOSTERONE RECEPTORS [J].

FUNDER, JW ;

FELDMAN, D ;

HIGHLAND, E ;

EDELMAN, IS .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (10) :1493-1501

[5]

GOCHMAN N, 1962, J PHARMACOL EXP THER, V135, P3

[6] ANTAGONISM OF FLUDROCORTISONE BY SPIRONOLACTONE AND CANRENONE [J].

HUSTON, GJ ;

TURNER, P ;

LEIGHTON, M .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1976, 3 (01) :201-204

[7] SPIRONOLACTONE - DISPOSITION, METABOLISM, PHARMACODYNAMICS, AND BIOAVAILABILITY [J].

KARIM, A .

DRUG METABOLISM REVIEWS, 1978, 8 (01) :151-188

[8]

OVERDIEK HWP, 1985, CLIN PHARMACOL THER, V38, P569

[9] INFLUENCE OF FOOD ON THE BIOAVAILABILITY OF SPIRONOLACTONE [J].

OVERDIEK, HWPM ;

MERKUS, FWHM .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1986, 40 (05) :531-536

[10] DETERMINATION OF THE SERUM CONCENTRATION OF SPIRONOLACTONE AND ITS METABOLITES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

OVERDIEK, JWPM ;

HERMENS, WAJJ ;

MERKUS, FWHM .

JOURNAL OF CHROMATOGRAPHY, 1985, 341 (02) :279-285

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