BEHAVIORAL-EFFECTS OF MODULATORS OF ATP-SENSITIVE K+ CHANNELS IN THE RAT DORSAL PALLIDUM

被引：10

作者：

AMALRIC, M ^{[1
]}

HEURTEAUX, C ^{[1
]}

NIEOULLON, A ^{[1
]}

LAZDUNSKI, M ^{[1
]}

机构：

[1] UNIV NICE SOPHIA ANTIPOLIS,INST PHARMACOL MOLEC & CELLULAIRE,CNRS,UPR 411,F-06560 VALBONNE,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 217卷 / 01期

关键词：

SULFONYLUREAS; K+ CHANNELS (ATP-SENSITIVE); MOTOR CONTROL; DORSAL PALLIDUM;

D O I：

10.1016/0014-2999(92)90513-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of the potent ATP-sensitive K+ channel blocker glipizide were measured on the locomotor activity of rats after bilateral intracerebral administration into the dorsal pallidum. Glipizide (10 pmol) was found to reduce spontaneous locomotor activity measured during the night cycle of the rats, whereas the ATP-sensitive K+ channel activator (-)-cromakalim (5 fmol) enhanced spontaneous locomotor activity. Glipizide (0.5, 2.5 and 10 pmol) was also found to depress noticeably d-amphetamine-induced locomotor activity (1 mg/kg s.c.). These results are in agreement with the idea that ATP-dependent potassium channels within the dorsal pallidum are involved in controlling motor activity in the rat.

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收藏

页码：71 / 77

页数：7

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