ACCUMULATION OF AMYLOID PRECURSOR PROTEIN IN BRAIN-LESIONS OF PATIENTS WITH PICK DISEASE

被引：7

作者：

YASUHARA, O

AIMI, Y

MCGEER, EG

MCGEER, PL

机构：

[1] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,VANCOUVER V6T 1Z3,BC,CANADA

[2] UNIV BRITISH COLUMBIA,CTR NEURODEGENERAT DISORDERS,VANCOUVER V6T 1Z3,BC,CANADA

来源：

NEUROSCIENCE LETTERS | 1994年 / 171卷 / 1-2期

关键词：

AMYLOID PRECURSOR PROTEIN; PICK BODY; BALLOONED NEURON; IMMUNOHISTOCHEMISTRY; ALZ-50; ALZHEIMER DISEASE;

D O I：

10.1016/0304-3940(94)90605-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of amyloid precursor protein (APP) was examined immunohistochemically in Pick disease brain using several antibodies to various segments of APP. Some neurons, including ballooned neurons, were intensely stained with antibodies to all but the N-terminal APP segment. However, Pick bodies were labeled with the antibody to that segment as well as the antibody to intermediate segment of APP. The pattern was similar to that previously observed for Alzheimer neurofibillary tangles. These data provide additional evidence that Pick bodies and neurofibillary tangles share some immunohistochemical characteristics.

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页码：63 / 66

页数：4

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