CORRELATIONS AMONG THE DNA BINDING/CLEAVING SPECIFICITIES OF SMALL MOLECULES REVEALED BY DOUBLE-STRAND AFFINITY CLEAVING

被引：6

作者：

GRIFFIN, JH

机构：

[1] Department of Chemistry, Stanford University, Stanford

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/0960-894X(94)00461-N

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A DNA double-strand affinity cleaving assay reveals clear positive and negative correlations among the DNA cleavage specificities of a series of minor groove binding/cleaving agents: [SalenMn(III)]+, neocarzinostatin, bleomycin:Fe, and methidiumpropyl-EDTA:Fe.

引用

收藏

页码：73 / 76

页数：4

相关论文

共 29 条

[1] CHEMICAL CONVERSION OF A DNA-BINDING PROTEIN INTO A SITE-SPECIFIC NUCLEASE [J].

CHEN, CHB ;

SIGMAN, DS .

SCIENCE, 1987, 237 (4819) :1197-1201

[2] SEQUENCE-SPECIFIC SCISSION OF DNA BY THE CHEMICAL NUCLEASE ACTIVITY OF 1,10-PHENANTHROLINE-COPPER(I) TARGETED BY RNA [J].

CHEN, CHB ;

GORIN, MB ;

SIGMAN, DS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :4206-4210

[3] SEQUENCE-SELECTIVE HYDROLYSIS OF DUPLEX DNA BY AN OLIGONUCLEOTIDE-DIRECTED NUCLEASE [J].

COREY, DR ;

PEI, D ;

SCHULTZ, PG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (22) :8523-8525

[4] SEQUENCE SPECIFIC CLEAVAGE OF DNA BY ANTI-TUMOR ANTIBIOTICS NEOCARZINOSTATIN AND BLEOMYCIN [J].

DANDREA, AD ;

HASELTINE, WA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (08) :3608-3612

[5] DESIGN OF SEQUENCE-SPECIFIC DNA-BINDING MOLECULES [J].

DERVAN, PB .

SCIENCE, 1986, 232 (4749) :464-471

[6] DNA STRUCTURAL VARIATIONS IN THE ESCHERICHIA-COLI TYRT-PROMOTER [J].

DREW, HR ;

TRAVERS, AA .

CELL, 1984, 37 (02) :491-502

[7] CONVERSION OF A HELIX-TURN-HELIX MOTIF SEQUENCE-SPECIFIC DNA-BINDING PROTEIN INTO A SITE-SPECIFIC DNA CLEAVAGE AGENT [J].

EBRIGHT, RH ;

EBRIGHT, YW ;

PENDERGRAST, PS ;

GUNASEKERA, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :2882-2886

[8] SEQUENCE-SPECIFIC RECOGNITION AND CLEAVAGE OF DUPLEX DNA VIA TRIPLE-HELIX FORMATION BY OLIGONUCLEOTIDES COVALENTLY LINKED TO A PHENANTHROLINE COPPER CHELATE [J].

FRANCOIS, JC ;

SAISONBEHMOARAS, T ;

BARBIER, C ;

CHASSIGNOL, M ;

THUONG, NT ;

HELENE, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :9702-9706

[9] SPECIFIC DNA CLEAVAGE MEDIATED BY [SALENMN(III)]+ [J].

GRAVERT, DJ ;

GRIFFIN, JH .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (04) :820-822

[10] NUCLEOTIDE SPECIFICITY IN DNA SCISSION BY NEOCARZINOSTATIN [J].

HATAYAMA, T ;

GOLDBERG, IH ;

TAKESHITA, M ;

GROLLMAN, AP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (08) :3603-3607