RETINAL GANGLION-CELLS EXPRESS A CGMP-GATED CATION CONDUCTANCE ACTIVATABLE BY NITRIC-OXIDE DONORS

被引：229

作者：

AHMAD, I

LEINDERSZUFALL, T

KOCSIS, JD

SHEPHERD, GM

ZUFALL, F

BARNSTABLE, CJ

机构：

[1] YALE UNIV, SCH MED, DEPT NEUROL, NEW HAVEN, CT 06510 USA

[2] YALE UNIV, SCH MED, NEUROBIOL SECT, NEW HAVEN, CT 06510 USA

来源：

NEURON | 1994年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0896-6273(94)90160-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have identified a putative cGMP-gated cation conductance in rat retinal ganglion cells. Both in situ hybridization and polymerase chain reaction amplification detected transcripts in ganglion cells that were highly homologous to the cGMP-gated cation channel expressed in rod photoreceptors. Whole-cell patch-clamp recordings detected a current stimulated by cGMP due to activation of nonselective cation channels. This current had a reversal potential near 0 mV, showed some outward rectification, and could be blocked by Cd2+. The current could also be activated by a phosphodiesterase inhibitor and the nitric oxide donors sodium nitroprusside and S-nitrosocysteine. We propose that nitric oxide released from an identified subpopulation of amacrine cells may activate this channel to modulate ganglion cell activity.

引用

页码：155 / 165

页数：11

共 61 条

[31] PRIMARY STRUCTURE OF CAMP-GATED CHANNEL FROM BOVINE OLFACTORY EPITHELIUM
LUDWIG, J
MARGALIT, T
EISMANN, E
LANCET, D
KAUPP, UB
[J]. FEBS LETTERS, 1990, 270 (1-2): : 24 - 29
[32] Massey S.C., 1990, Progress in Retinal Research, V9, P399, DOI 10.1016/0278-4327(90)90013-8
[33] CONCOMITANT ACTIVATION OF 2 TYPES OF GLUTAMATE RECEPTOR MEDIATES EXCITATION OF SALAMANDER RETINAL GANGLION-CELLS
MITTMAN, S
TAYLOR, WR
COPENHAGEN, DR
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1990, 428 : 175 - 197
[34] MONCADA S, 1991, PHARMACOL REV, V43, P109
[35] A CYCLIC NUCLEOTIDE-GATED CONDUCTANCE IN OLFACTORY RECEPTOR CILIA
NAKAMURA, T
GOLD, GH
[J]. NATURE, 1987, 325 (6103) : 442 - 444
[36] CGMP-GATED CONDUCTANCE IN RETINAL BIPOLAR CELLS IS SUPPRESSED BY THE PHOTORECEPTOR TRANSMITTER
NAWY, S
JAHR, CE
[J]. NEURON, 1991, 7 (04) : 677 - 683
[37] SUPPRESSION BY GLUTAMATE OF CGMP-ACTIVATED CONDUCTANCE IN RETINAL BIPOLAR CELLS
NAWY, S
JAHR, CE
[J]. NATURE, 1990, 346 (6281) : 269 - 271
[38] NESTLER EJ, 1984, PROTEIN PHOSPHORYLAT, P398
[39] Pober J S, 1979, Adv Cyclic Nucleotide Res, V11, P265
[40] RAPORT CJ, 1989, J BIOL CHEM, V264, P7122

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