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ISOLATION AND CHARACTERIZATION OF THE ALPHA-PLATELET-DERIVED GROWTH-FACTOR RECEPTOR FROM RAT OLFACTORY EPITHELIUM

被引：67
作者：
LEE, KH
BOWENPOPE, DF
REED, RR
机构：
[1] JOHNS HOPKINS UNIV,SCH MED,HOWARD HUGHES MED INST,DEPT MOLEC BIOL & GENET,GENET LAB,BALTIMORE,MD 21205
[2] UNIV WASHINGTON,SCH MED,DEPT PATHOL,SEATTLE,WA 98195
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 05期
关键词：
D O I：
10.1128/MCB.10.5.2237
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have cloned and characterized a new member of the receptor tyrosine kinase family. The cDNA clone, isolated from a rat olfactory cDNA library, has considerable homology to the family of receptors that includes the colony-stimulating factor 1 receptor, the c-kit proto-oncogene, and the platelet-derived growth factor (PDGF) receptors. Analysis of DNA sequence homology, ligand-binding, and ligand-stimulated phoshorylation data suggests that this clone encodes the rat PDGF-A/B or α-receptor. Comparison of its sequence to those of other receptors allows us to postulate a mechanism for receptor dimerization and activation. The expression of the rat α-PDGF receptor in nonneuronal cells of the olfactory epithelium and in the olfactory bulb is consistent with a role for PDGF in glial cell generation.
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页码：2237 / 2246
页数：10
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