DESIGN AND SYNTHESIS OF A PROTOTYPICAL NONPEPTIDIC INHIBITOR MODEL FOR THE ENZYME RENIN

被引：31

作者：

HANESSIAN, S

RAGHAVAN, S

机构：

[1] Department of Chemistry, Montréal, Que. H3C 3J7, Universite Montreal P.O. Box 6128, Succ. Centre-ville

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(00)80364-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of non-peptidic acyclic and conformationally constrained compounds is described with the intention of designing models and chemical intermediates, for an inhibitor of the enzyme renin.

引用

页码：1697 / 1702

页数：6

共 54 条

[31] MAIBAUM J, COMMUNICATION
[32] MARTIN SF, 1992, SYNTHESIS-STUTTGART, P55
[33] AN EFFICIENT APPROACH TOWARD PYRROLIDINYLLACTONE SYSTEM CHARACTERISTIC OF THE STEMONA ALKALOIDS - LEWIS-ACID CATALYZED STEREOSELECTIVE REACTION OF N-BENZYLOXYCARBONYL-2-METHOXYPYRROLIDINE WITH 3-METHYL-2-TRIMETHYLSILYLOXYFURAN
MORIMOTO, Y
NISHIDA, K
HAYASHI, Y
SHIRAHAMA, H
[J]. TETRAHEDRON LETTERS, 1993, 34 (36) : 5773 - 5776
[34] DIASTEREOSELECTIVE SYNTHESIS OF THE HYDROXYETHYLENE DIPEPTIDE ISOSTERE OF LEU-VAL
NISHI, T
KATAOKA, M
MORISAWA, Y
[J]. CHEMISTRY LETTERS, 1989, (11) : 1993 - 1996
[35] OCAIN T D, 1991, Drugs of the Future, V16, P37
[36] PEARLMAN WM, 1967, TETRAHEDRON LETT, P1663
[37] PLATTNER JJ, 1987, ANNU REP MED CHEM, V22, P63
[38] PEPTIDOMIMETIC INHIBITORS OF RENIN INCORPORATING TOPOGRAPHICALLY MODIFIED ISOSTERES SPANNING THE P-1(-]P-3)-P-1' SITES
PLUMMER, M
HAMBY, JM
HINGORANI, G
BATLEY, BL
RAPUNDALO, ST
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (10) : 2119 - 2124
[39] PRASAD JVNV, 1990, TETRAHEDRON LETT, V31, P1803
[40] NONPEPTIDE RENIN INHIBITORS CONTAINING 2-(((3-PHENYLPROPYL)PHOSPHORYL)OXY)ALKANOIC ACID MOIETIES AS P-2-P-3 REPLACEMENTS
RADDATZ, P
MINCK, KO
RIPPMANN, F
SCHMITGES, CJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (04) : 486 - 497

← 1 2 3 4 5 6 →