DESIGN AND SYNTHESIS OF A PROTOTYPICAL NONPEPTIDIC INHIBITOR MODEL FOR THE ENZYME RENIN

被引:31
作者
HANESSIAN, S
RAGHAVAN, S
机构
[1] Department of Chemistry, Montréal, Que. H3C 3J7, Universite Montreal P.O. Box 6128, Succ. Centre-ville
关键词
D O I
10.1016/S0960-894X(00)80364-9
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The synthesis of non-peptidic acyclic and conformationally constrained compounds is described with the intention of designing models and chemical intermediates, for an inhibitor of the enzyme renin.
引用
收藏
页码:1697 / 1702
页数:6
相关论文
共 54 条
  • [31] MAIBAUM J, COMMUNICATION
  • [32] MARTIN SF, 1992, SYNTHESIS-STUTTGART, P55
  • [33] AN EFFICIENT APPROACH TOWARD PYRROLIDINYLLACTONE SYSTEM CHARACTERISTIC OF THE STEMONA ALKALOIDS - LEWIS-ACID CATALYZED STEREOSELECTIVE REACTION OF N-BENZYLOXYCARBONYL-2-METHOXYPYRROLIDINE WITH 3-METHYL-2-TRIMETHYLSILYLOXYFURAN
    MORIMOTO, Y
    NISHIDA, K
    HAYASHI, Y
    SHIRAHAMA, H
    [J]. TETRAHEDRON LETTERS, 1993, 34 (36) : 5773 - 5776
  • [34] DIASTEREOSELECTIVE SYNTHESIS OF THE HYDROXYETHYLENE DIPEPTIDE ISOSTERE OF LEU-VAL
    NISHI, T
    KATAOKA, M
    MORISAWA, Y
    [J]. CHEMISTRY LETTERS, 1989, (11) : 1993 - 1996
  • [35] OCAIN T D, 1991, Drugs of the Future, V16, P37
  • [36] PEARLMAN WM, 1967, TETRAHEDRON LETT, P1663
  • [37] PLATTNER JJ, 1987, ANNU REP MED CHEM, V22, P63
  • [38] PEPTIDOMIMETIC INHIBITORS OF RENIN INCORPORATING TOPOGRAPHICALLY MODIFIED ISOSTERES SPANNING THE P-1(-]P-3)-P-1' SITES
    PLUMMER, M
    HAMBY, JM
    HINGORANI, G
    BATLEY, BL
    RAPUNDALO, ST
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (10) : 2119 - 2124
  • [39] PRASAD JVNV, 1990, TETRAHEDRON LETT, V31, P1803
  • [40] NONPEPTIDE RENIN INHIBITORS CONTAINING 2-(((3-PHENYLPROPYL)PHOSPHORYL)OXY)ALKANOIC ACID MOIETIES AS P-2-P-3 REPLACEMENTS
    RADDATZ, P
    MINCK, KO
    RIPPMANN, F
    SCHMITGES, CJ
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (04) : 486 - 497