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DESIGN AND SYNTHESIS OF A PROTOTYPICAL NONPEPTIDIC INHIBITOR MODEL FOR THE ENZYME RENIN
被引:31
作者
:
HANESSIAN, S
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Chemistry, Montréal, Que. H3C 3J7, Universite Montreal P.O. Box 6128, Succ. Centre-ville
HANESSIAN, S
RAGHAVAN, S
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Chemistry, Montréal, Que. H3C 3J7, Universite Montreal P.O. Box 6128, Succ. Centre-ville
RAGHAVAN, S
机构
:
[1]
Department of Chemistry, Montréal, Que. H3C 3J7, Universite Montreal P.O. Box 6128, Succ. Centre-ville
来源
:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
|
1994年
/ 4卷
/ 14期
关键词
:
D O I
:
10.1016/S0960-894X(00)80364-9
中图分类号
:
R914 [药物化学];
学科分类号
:
100701 ;
摘要
:
The synthesis of non-peptidic acyclic and conformationally constrained compounds is described with the intention of designing models and chemical intermediates, for an inhibitor of the enzyme renin.
引用
收藏
页码:1697 / 1702
页数:6
相关论文
共 54 条
[41]
THE CRYSTAL-STRUCTURES OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION-STATE ANALOG INHIBITOR
RAHUEL, J
论文数:
0
引用数:
0
h-index:
0
机构:
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
RAHUEL, J
PRIESTLE, JP
论文数:
0
引用数:
0
h-index:
0
机构:
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
PRIESTLE, JP
GRUTTER, MG
论文数:
0
引用数:
0
h-index:
0
机构:
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
GRUTTER, MG
[J].
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EFFICIENT TOTAL SYNTHESIS OF (1R,2R,3R,9R,9AR)-1,2,3,9-TETRAHYDROXYQUINOLIZIDINE AND ITS ENANTIOMER
RASSU, G
论文数:
0
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0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
RASSU, G
CASIRAGHI, G
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
CASIRAGHI, G
PINNA, L
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
PINNA, L
SPANU, P
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
SPANU, P
ULGHERI, F
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
ULGHERI, F
CORNIA, M
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
CORNIA, M
ZANARDI, F
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0
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ROSENBERG, SH
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0
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0
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Cardiovascular Research Division, Abbott Laboratories, Abbott Park
ROSENBERG, SH
BOYD, SA
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SAKURAI, M
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SAKURAI, M
SAITO, F
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
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OHATA, Y
论文数:
0
引用数:
0
h-index:
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机构:
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
OHATA, Y
YABE, Y
论文数:
0
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0
h-index:
0
机构:
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
YABE, Y
NISHI, T
论文数:
0
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0
h-index:
0
机构:
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
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[J].
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SHIOZAKI, M
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SHIOZAKI, M
KOBAYASHI, Y
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
KOBAYASHI, Y
HATA, T
论文数:
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h-index:
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SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
HATA, T
FURUKAWA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
FURUKAWA, Y
[J].
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1991,
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SZELKE, M
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0
引用数:
0
h-index:
0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
SZELKE, M
LECKIE, B
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0
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h-index:
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机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
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HALLETT, A
论文数:
0
引用数:
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h-index:
0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
HALLETT, A
JONES, DM
论文数:
0
引用数:
0
h-index:
0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
JONES, DM
SUEIRAS, J
论文数:
0
引用数:
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0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
SUEIRAS, J
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论文数:
0
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0
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WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
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[41]
THE CRYSTAL-STRUCTURES OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION-STATE ANALOG INHIBITOR
RAHUEL, J
论文数:
0
引用数:
0
h-index:
0
机构:
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
RAHUEL, J
PRIESTLE, JP
论文数:
0
引用数:
0
h-index:
0
机构:
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
PRIESTLE, JP
GRUTTER, MG
论文数:
0
引用数:
0
h-index:
0
机构:
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
CIBA GEIGY AG,DIV PHARMACEUT,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
GRUTTER, MG
[J].
JOURNAL OF STRUCTURAL BIOLOGY,
1991,
107
(03)
: 227
-
236
[42]
EFFICIENT TOTAL SYNTHESIS OF (1R,2R,3R,9R,9AR)-1,2,3,9-TETRAHYDROXYQUINOLIZIDINE AND ITS ENANTIOMER
RASSU, G
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
RASSU, G
CASIRAGHI, G
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
CASIRAGHI, G
PINNA, L
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
PINNA, L
SPANU, P
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
SPANU, P
ULGHERI, F
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
ULGHERI, F
CORNIA, M
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
CORNIA, M
ZANARDI, F
论文数:
0
引用数:
0
h-index:
0
机构:
CNR,IST APPL TECN CHIM AVANZATE,I-07100 SASSARI,ITALY
ZANARDI, F
[J].
TETRAHEDRON,
1993,
49
(30)
: 6627
-
6636
[43]
A STEREOSELECTIVE SYNTHESIS OF HYDROXYETHYLENE AND ERYTHRO-DIHYDROXYETHYLENE DIPEPTIDE ISOSTERES - A FACIAL SELECTIVE ANTI-ALDOL REACTION
ROSENBERG, SH
论文数:
0
引用数:
0
h-index:
0
机构:
Cardiovascular Research Division, Abbott Laboratories, Abbott Park
ROSENBERG, SH
BOYD, SA
论文数:
0
引用数:
0
h-index:
0
机构:
Cardiovascular Research Division, Abbott Laboratories, Abbott Park
BOYD, SA
MANTEI, RA
论文数:
0
引用数:
0
h-index:
0
机构:
Cardiovascular Research Division, Abbott Laboratories, Abbott Park
MANTEI, RA
[J].
TETRAHEDRON LETTERS,
1991,
32
(45)
: 6507
-
6508
[44]
AN EFFICIENT SYNTHESIS OF GAMMA-LACTONES AS PRECURSORS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERE
SAKURAI, M
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SAKURAI, M
SAITO, F
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SAITO, F
OHATA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
OHATA, Y
YABE, Y
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
YABE, Y
NISHI, T
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,MED CHEM RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
NISHI, T
[J].
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS,
1992,
(21)
: 1562
-
1563
[45]
SYNTHESIS OF RENIN INHIBITORS POSSESSING HYDROXYETHYLENE ISOSTERE RESIDUE FROM 3,4,6-TRI-O-ACETYL-D-GLUCAL VIA LACTONE PRECURSOR
SHIOZAKI, M
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SHIOZAKI, M
KOBAYASHI, Y
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
KOBAYASHI, Y
HATA, T
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
HATA, T
FURUKAWA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
FURUKAWA, Y
[J].
TETRAHEDRON,
1991,
47
(16-17)
: 2785
-
2800
[46]
POTENT NEW INHIBITORS OF HUMAN RENIN
SZELKE, M
论文数:
0
引用数:
0
h-index:
0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
SZELKE, M
LECKIE, B
论文数:
0
引用数:
0
h-index:
0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
LECKIE, B
HALLETT, A
论文数:
0
引用数:
0
h-index:
0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
HALLETT, A
JONES, DM
论文数:
0
引用数:
0
h-index:
0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
JONES, DM
SUEIRAS, J
论文数:
0
引用数:
0
h-index:
0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
SUEIRAS, J
ATRASH, B
论文数:
0
引用数:
0
h-index:
0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
ATRASH, B
LEVER, AF
论文数:
0
引用数:
0
h-index:
0
机构:
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
WESTERN INFIRM,MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND
LEVER, AF
[J].
NATURE,
1982,
299
(5883)
: 555
-
557
[47]
Szelke M., 1983, PEPTIDES STRUCTURE F, P579
[48]
SZEWCZUK Z, 1992, INT J PEPT PROT RES, V40, P233
[49]
THE AMINO TERMINAL AMINO-ACID-SEQUENCE OF HUMAN ANGIOTENSINOGEN
TEWKSBURY, DA
论文数:
0
引用数:
0
h-index:
0
机构:
MARSHFIELD CLIN,MARSHFIELD,WI 54449
TEWKSBURY, DA
DART, RA
论文数:
0
引用数:
0
h-index:
0
机构:
MARSHFIELD CLIN,MARSHFIELD,WI 54449
DART, RA
TRAVIS, J
论文数:
0
引用数:
0
h-index:
0
机构:
MARSHFIELD CLIN,MARSHFIELD,WI 54449
TRAVIS, J
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1981,
99
(04)
: 1311
-
1315
[50]
WAEBER B, 1986, HDB HYPERTENSION, V8, P489
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