MDL 74147, A NOVEL SELECTIVE AND SOLUBLE INHIBITOR OF HUMAN RENIN - SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP, SPECIES AND PROTEASE SELECTIVITIES

被引：14

作者：

SCHIRLIN, D ^{[1
]}

TARNUS, C ^{[1
]}

BALTZER, S ^{[1
]}

REMY, JM ^{[1
]}

机构：

[1] MARION MERRELL DOW RES INST,DEPT ENZYMOL,F-67009 STRASBOURG,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(00)80383-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a novel, potent and soluble inhibitor of human renin bearing a beta-amino-alpha,alpha-difluoroketone functionality is described. Its structure-activity relationship, species and protease selectivities are discussed.

引用

页码：651 / 654

页数：4

共 9 条

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[9] ALPHA,ALPHA-DIFLUORO-BETA-AMINODEOXYSTATINE-CONTAINING RENIN INHIBITORY PEPTIDES
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