DESIGN AND SYNTHESIS OF A PROTOTYPE MODEL ANTAGONIST OF TACHYKININ NK-2 RECEPTOR

被引：35

作者：

HANESSIAN, S ^{[1
]}

RONAN, B ^{[1
]}

LAOUI, A ^{[1
]}

机构：

[1] RHONE POULENC RORER SA, CENT RES, CTR RECH VITRY ALFORTVILLE, F-94403 VITRY, FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80369-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A conformationally biased bicyclic lactam containing strategically placed hydrophobic groups was synthesized as a prototype model antagonist molecule of the NK-2 receptor.

引用

页码：1397 / 1400

页数：4

共 51 条

[11] THE TOTAL SYNTHESES OF THE ISODITYROSINE-DERIVED CYCLIC TRIPEPTIDES OF4949-III AND K-13 - DETERMINATION OF THE ABSOLUTE-CONFIGURATION OF K-13 [J].

EVANS, DA ;

ELLMAN, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (03) :1063-1072

[12] ELECTROPHILIC AZIDE TRANSFER TO CHIRAL ENOLATES - A GENERAL-APPROACH TO THE ASYMMETRIC-SYNTHESIS OF ALPHA-AMINO-ACIDS [J].

EVANS, DA ;

BRITTON, TC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (22) :6881-6883

[13] TOTAL SYNTHESIS OF THE ANGIOTENSIN-CONVERTING ENZYME INHIBITOR-A58365A - ON THE USE OF PYROGLUTAMATE AS A CHIRAL EDUCT [J].

FANG, FG ;

DANISHEFSKY, SJ .

TETRAHEDRON LETTERS, 1989, 30 (28) :3621-3624

[14] SPANTIDE-II, AN EFFECTIVE TACHYKININ ANTAGONIST HAVING HIGH POTENCY AND NEGLIGIBLE NEUROTOXICITY [J].

FOLKERS, K ;

FENG, DM ;

ASANO, N ;

HAKANSON, R ;

WEISENFELDHALLIN, Z ;

LEANDER, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) :4833-4835

[15] PEPTIDOMIMETICS FOR RECEPTOR LIGANDS DISCOVERY, DEVELOPMENT, AND MEDICAL PERSPECTIVES [J].

GIANNIS, A .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1993, 32 (09) :1244-1267

[16]

GUILLAUME JM, 1993, 3RD ANN M NEUR CLUB

[17] STUDIES ON NEUROKININ ANTAGONISTS .1. THE DESIGN OF NOVEL TRIPEPTIDES POSSESSING THE GLUTAMINYL-DEUTERIUM-TRYPTOPHYLPHENYLALANINE SEQUENCE AS SUBSTANCE-P ANTAGONISTS [J].

HAGIWARA, D ;

MIYAKE, H ;

MORIMOTO, H ;

MURAI, M ;

FUJII, T ;

MATSUO, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (11) :2015-2025

[18] A FACILE SYNTHESIS OF THE NOVEL NEUROKININ-A ANTAGONIST SR-48968 [J].

HALE, JJ ;

FINKE, PE ;

MACCOSS, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (02) :319-322

[19] HIGHLY STEREOCONTROLLED SYNTHESES OF 2,3-DISUBSTITUTED 1,4-BUTYROLACTONES USING IONIC AND FREE-RADICAL REACTIONS [J].

HANESSIAN, S ;

VANASSE, B ;

YANG, H ;

ALPEGIANI, M .

CANADIAN JOURNAL OF CHEMISTRY, 1993, 71 (09) :1407-1411

[20] A NEW CLASS OF HIGH-AFFINITY LIGANDS FOR THE NEUROKININ-A NK2 RECEPTOR - PSI(CH2NR) REDUCED PEPTIDE-BOND ANALOGS OF NEUROKININ-A4-10 [J].

HARBESON, SL ;

SHATZER, SA ;

LE, TB ;

BUCK, SH .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (21) :3949-3955

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