A powerful new nitrile hydratase for organic synthesis - Aromatic and heteroaromatic nitrile hydrolyses - A rationalisation

被引：30

作者：

MethCohn, O

Wang, MX

机构：

[1] Chemistry Department, University of Sunderland, Sunderland

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 52期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/0040-4039(95)02048-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A powerful new nitrile hydratase organism, Rhodococcus rhodocrous AJ270 has been isolated that efficiently hydrolyses all kinds of nitriles to amides and/or acids. This paper shows that aromatic and heterocyclic nitriles are readily hydrolysed to acids but, that those bearing an adjacent-substituent (which may be an ortho substituent or an adjacent heteroatom in the ring) give amides in good yield but only slowly proceed to adds.

引用

页码：9561 / 9564

页数：4

共 12 条

[1]

BENGISGARBER C, 1988, APPL MICROBIOL BIOT, V29, P2598

[2]

BLAKEY AJ, 1995, FEMS MICROBIOL LETT, V129, P57

[3] SELECTIVE HYDROLYSIS OF NITRILES UNDER MILD CONDITIONS BY AN ENZYME [J].