THC-INDUCED PLACE AND TASTE-AVERSIONS IN LEWIS AND SPRAGUE-DAWLEY RATS

被引：118

作者：

PARKER, LA

GILLIES, T

机构：

来源：

BEHAVIORAL NEUROSCIENCE | 1995年 / 109卷 / 01期

关键词：

D O I：

10.1037/0735-7044.109.1.71

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The hedonic properties of delta-9-tetrahydrocannabinol (THC) were assessed in place and taste conditioning paradigms in both Lewis and Sprague-Dawley rat strains. THC produced place avoidance, taste avoidance, and aversive taste reactivity responses in both strains. The Lewis strain displayed more aversive taste reactions and a stronger taste avoidance when conditioned with lower doses of THC than did the Sprague-Dawley strain of rats. THC is an anomalous drug of abuse that appears to be aversive to rats when assessed by these measures.

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页码：71 / 78

页数：8

相关论文

共 42 条

[1] POSSIBLE INVOLVEMENT OF CENTRAL FACTORS IN MEDIATION OF CONDITIONED TASTE-AVERSION [J].

AMIT, Z ;

LEVITAN, DE ;

BROWN, ZW ;

ROGAN, F .

NEUROPHARMACOLOGY, 1977, 16 (02) :121-124

[2] PLACE CONDITIONING WITH MORPHINE AND PHENCYCLIDINE - DOSE DEPENDENT EFFECTS [J].

BARR, GA ;

PAREDES, W ;

BRIDGER, WH .

LIFE SCIENCES, 1985, 36 (04) :363-368

[3] CONDITIONING OF FOOD AVERSIONS BY INJECTIONS OF PSYCHOACTIVE DRUGS [J].

BERGER, BD .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1972, 81 (01) :21-&

[4] PHENCYCLIDINE-INDUCED POTENTIATION OF BRAIN-STIMULATION REWARD - ACUTE EFFECTS ARE NOT ALTERED BY REPEATED ADMINISTRATION [J].

CARLEZON, WA ;

WISE, RA .

PSYCHOPHARMACOLOGY, 1993, 111 (04) :402-408

[5] EVALUATION OF A SUSPENSION SYSTEM FOR INTRAVENOUS SELF-ADMINISTRATION STUDIES OF WATER-INSOLUBLE COMPOUNDS IN RHESUS-MONKEY [J].

CARNEY, JM ;

UWAYDAH, IM ;

BALSTER, RL .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1977, 7 (04) :357-364

[6] CONDITIONED TASTE AVERSIONS PRODUCED BY ACTIVE AND INACTIVE CANNABINOIDS [J].

CORCORAN, ME ;

BOLOTOW, I ;

AMIT, Z ;

MCCAUGHRAN, JA .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1974, 2 (06) :725-728

[7]

Cowan A, 1990, TESTING EVALUATION D, P211

[8] DELTA9-TETRAHYDROCANNABINOL - AVERSIVE EFFECTS IN RAT AT HIGH DOES [J].

ELSMORE, TF ;

FLETCHER, GV .

SCIENCE, 1972, 175 (4024) :911-&

[9]

FARBER PD, 1976, PHYSIOL PSYCHOL, V4, P365

[10] INJECTIBLE DISPERSION OF DELTA9-TETRAHYDROCANNABINOL IN SALINE USING POLYVINYLPYRROLIDONE [J].

FENIMORE, DC ;

LOY, PR .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1971, 23 (04) :310-&

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