SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF THIAZOLINOMETHYL-2(3H)-BENZOXAZOLONE DERIVATIVES .1.

被引：14

作者：

EROL, DD ^{[1
]}

AYTEMIR, MD ^{[1
]}

YULUG, N ^{[1
]}

机构：

[1] EYLUL UNIV 9,FAC MED,DEPT MICROBIOL,BORNOVA,TURKEY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 30卷 / 06期

关键词：

THIAZOLINOMETHYL-2(3H)-BENZOXAZOLONE DERIVATIVE; ANTIBACTERIAL AGENT; ANTIFUNGAL AGENT;

D O I：

10.1016/0223-5234(96)88264-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A number of thiazolinoalkyl-2(3H)-benzoxazolones have been synthesized by using cyano derivatives of 6-acyl-2(3H)-benzoxazolones with cysteamine HCl. Their antibacterial and antifungal activities have been evaluated. The chemical structures have been proved by means of their IR, H-1-NMR and mass spectroscopic data and by elemental analysis. The antimicrobial activity of compounds was investigated by tube dilution and disk techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus faecalis RSKK 10541) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis, C stellatoidea). Inhibitory effects were observed for many compounds against C albicans, eg, compounds 3b and 3c MIC = 25 mu g/ml, C pseudotropicalis, eg, compound 3b MIC = 12.5 mu g/ml, and P aeruginosa and S faecalis, eg, compound 3c, MIC = 25 mu g/ml.

引用

页码：521 / 524

页数：4

共 25 条

[1]

POTENTIAL ANTI-MICROBIALS .2. SYNTHESIS AND INVITRO ANTIMICROBIAL EVALUATION OF SOME THIAZOLO[4,5-D]PYRIMIDINES [J].