The technical possibilities of the microbial production of acetone, butanol and ethanol (ABE) from potato waste using in-line solvent recovery, are evaluated. Clostridium acetobutylicum DSM 1731 produces up to 20 g-l-1 of solvents when grown on a medium containing 14% (w/v) potato powder. Using a polypropylene perstraction system and a oleyl alcohol/decane mixture as the extractant, the product yield (based on total solvents and potato dry weight) increased from 0.13 g-g-1 to 0.23 g.g-1. The recovery system worked well for 50 h, after which membrane fouling frustrated proper operation. In the second system a microfiltration step was incorporated whereas the solvents were extracted through a hydrophilic membrane using fatty acid methyl esters from sunflower oil as an extractant. This process configuration resulted in a comparable increase of ABE production.