2 NEW CYTOTOXIC CYTOCHALASINS FROM XYLARIA-OBOVATA

被引：44

作者：

DAGNE, E

GUNATILAKA, AAL

ASMELLASH, S

ABATE, D

KINGSTON, DGI

HOFMANN, GA

JOHNSON, RK

机构：

[1] UNIV ADDIS ABABA, FAC SCI, ADDIS ABABA, ETHIOPIA

[2] SMITHKLINE BEECHAM PHARMACEUT, RES & DEV, KING OF PRUSSIA, PA 19406 USA

来源：

TETRAHEDRON | 1994年 / 50卷 / 19期

关键词：

D O I：

10.1016/S0040-4020(01)85632-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new cytotoxic cytochalasins were isolated by brine shrimp bioassay-guided fractionation from a culture of the wood inhabiting fungus, Xylaria obovata. Their structures were determined as 19,20-epoxycytochalasin Q (1) and its deacetyl analog 2 by the application of spectroscopic techniques and chemical correlation with cytochalasin R. Acetylation of 2 yielded 1. Both 1 and 2 were cytotoxic but were found to be inactive in an HIV-protease inhibitory assay and a mechanism-based DNA damaging yeast assay.

引用

页码：5615 / 5620

页数：6

共 12 条

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